Analysis of sevoflurane degradation products in vapor phase samples

Sevoflurane degradation products were measured by GC-flame ionization detection in vapor phase samples using manual and automated injection methods. Sample handling techniques allowed the transfer and storage of samples for up to 72 h. Compound A, fluoromethyl 2,2-difluoro-1-(trifuloromethyl)vinyl e...

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Bibliographic Details
Published in:Journal of chromatography. B, Biomedical applications Biomedical applications, 1995-06, Vol.668 (1), p.41-52
Main Authors: Cunningham, David D., Webster, Jack, Nelson, Don, Williamson, Brad
Format: Article
Language:English
Subjects:
Anesthetics - analysis
Anesthetics - metabolism
Biodegradation, Environmental
Chromatography, Gas
Drug Stability
Ethers - analysis
Ethers - metabolism
Flame Ionization
Humans
Methyl Ethers
Models, Biological
Reproducibility of Results
Sevoflurane
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Summary:Sevoflurane degradation products were measured by GC-flame ionization detection in vapor phase samples using manual and automated injection methods. Sample handling techniques allowed the transfer and storage of samples for up to 72 h. Compound A, fluoromethyl 2,2-difluoro-1-(trifuloromethyl)vinyl ether, was the major vapor phase degradation product formed in simulated clinical conditions. Recoveries of 4–32 ppm (v/v) compound A concentrations using the manual method were in the range of 88–117% ( n = 12, mean = 102%, R.S.D. = 9%).
ISSN:0378-4347
1572-6495
DOI:10.1016/0378-4347(95)00069-U