Reduction of endothelial cell number by cataract operation with intraocular thymoxamine administration. A randomized, double-blind study

Thymoxamine, an alpha-1-receptor blocker, considerably enhances miosis when given intraocularly in combination with acetylcholine. We investigated whether intraocular use of thymoxamine 0.02% reduced the number of endothelial cells. After phacoemulsification of 59 eyes, either thymoxamine 0.02%, ace...

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Bibliographic Details
Published in:Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 1997-02, Vol.94 (2), p.136
Main Authors: Schwenn, O K, Schellein, O, Pfeiffer, N, Grehn, F
Format: Article
Language:ger
Subjects:
Acetylcholine - administration & dosage
Acetylcholine - adverse effects
Adult
Aged
Aged, 80 and over
Cell Count - drug effects
Double-Blind Method
Endothelium, Corneal - drug effects
Female
Humans
Lenses, Intraocular
Male
Middle Aged
Miotics - administration & dosage
Miotics - adverse effects
Moxisylyte - administration & dosage
Moxisylyte - adverse effects
Ophthalmic Solutions
Phacoemulsification
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Summary:Thymoxamine, an alpha-1-receptor blocker, considerably enhances miosis when given intraocularly in combination with acetylcholine. We investigated whether intraocular use of thymoxamine 0.02% reduced the number of endothelial cells. After phacoemulsification of 59 eyes, either thymoxamine 0.02%, acetylcholine 1.0% or buffered saline solution was given intraocularly. With a contact specular microscope, corneal endothelial cell photographs were taken on the day before treatment and 3 days and 6 weeks after surgery. There were no statistically significant differences between endothelial cell counts of eyes treated with thymoxamine (-7.2%), acetylcholine (-10.2%) or BSS (-9.4%). This study shows for the first time that thymoxamine, when given in the anterior chamber after phacoemulsification, does not cause a greater loss of endothelial cells than acetylcholine or buffered saline solution.
ISSN:0941-293X