Characterization of red blood cell aggregate formation using an analytical model of the ultrasonic backscattering coefficient

Ultrasound backscattering is well adapted to study the red blood cell (RBC) aggregation phenomenon and growth of RBC aggregates since the backscattered ultrasonic intensity depends on the sixth power of the mean radius of the scattering centers when considered as spherical. Thus, small variations of...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1997-07, Vol.44 (7), p.585-591
Main Authors: Sennaoui, A., Boynard, M., Pautou, C.
Format: Article
Language:English
Subjects:
Aggregates
Analytical models
Backscatter
Biological and medical sciences
Blood Sedimentation
Cell cycle, cell proliferation
Cell physiology
Erythrocyte Aggregation
Erythrocytes - diagnostic imaging
Fundamental and applied biological sciences. Psychology
Humans
Least-Squares Analysis
Models, Biological
Molecular and cellular biology
Normal Distribution
Red blood cells
Scattering
Time Factors
Time measurement
Ultrasonic imaging
Ultrasonic variables measurement
Ultrasonography - instrumentation
Ultrasonography - statistics & numerical data
Volume measurement
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Summary:Ultrasound backscattering is well adapted to study the red blood cell (RBC) aggregation phenomenon and growth of RBC aggregates since the backscattered ultrasonic intensity depends on the sixth power of the mean radius of the scattering centers when considered as spherical. Thus, small variations of aggregate size induce large variations of the backscattered intensity. From measurements of the ultrasonic backscattering coefficient (ultrasonic backscattering cross section per unit volume of suspension), an analytical model describing its variation versus time, for human aggregated red blood cells in sedimentation, is proposed. Results given by the model allow to define three phases in the phenomenon: 1) a starting phase characterized by a duration t/sub s/; 2) a stationary final phase beginning at time t/sub f/; 3) a growing intermediate phase characterized by its duration t/sub f/-t/sub s/. The analytical model has been applied to describe RBC aggregation in dextran 70,000 dalton of different concentrations, and at various hematocrits. Knowledge of the durations t/sub s/, t/sub f/ and the maximum slope s of the curve during the intermediate phase, determined with the model, allows a means to study RBC aggregate growth.
ISSN:0018-9294
1558-2531
DOI:10.1109/10.594899