Cholestyramine Influences Meal-Stimulated Pancreaticobiliary Function and Plasma Cholecystokinin Independent of Gastric Emptying and Food Digestion

• Published in: Scandinavian journal of gastroenterology 1997, Vol.32 (8), p.778-784
• Main Authors: Thimister, P. W. L., Hopman, W. P. M., Loualidi, A., Rosenbusch, G., Willems, H. L., Trijbels, F. J. M., Jansen, J. B. M. J.
• Format: Article
• Language: English
• Subjects: Adult; Amino acids; Amino Acids - administration & dosage; Amylases - drug effects; Amylases - secretion; Anticholesteremic Agents - administration & dosage; Biological and medical sciences; Cholecystokinin; Cholecystokinin - blood; Cholecystokinin - drug effects; Cholestyramine Resin - administration & dosage; Digestion - drug effects; Eating - physiology; Female; Gallbladder Emptying - drug effects; gallbladder motility; Gastric Emptying - drug effects; General pharmacology; Humans; Male; Medical sciences; pancreatic enzyme secretion; pancreatic polypeptide; Pancreatic Polypeptide - blood; Pancreatic Polypeptide - drug effects; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Radioimmunoassay; Reference Values; Sodium Chloride - administration & dosage
• ISSN: 0036-5521; 1502-7708
• DOI: 10.3109/00365529708996534

Background: Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. It is not known whether this effect occurs independently of alterations in gastric emptying or maldigestion of nutrients. Methods: We perfused 15 g of an amino acid meal intraduodenally for 60min in seven healthy volunteers, once with and once without cholestyramine. Intraduodenal perfusion of saline with or without cholestyramine (6 g/h) was started 60 min before the amino acid meal and continued for 2 h. Results: Cholestyramine markedly enhanced the incremental plasma cholecystokinin response to the meal from 36 ±12 to 139 ± 25 pmol/1 60 min (P < 0.005), incremental amylase output from 2.4 ± 0.7 to 5.7 ± 0.7 kU/h (P < 0.05), and incremental integrated gallbladder contraction from1948 ± 235 to 2840 ± 189% 60 min (P < 0.05). Conclusion: The enhancing effect of cholestyramine on postprandial gallbladder contraction, pancreatic enzyme secretion, and plasma cholecystokinin release is not dependent on gastric emptying rates or appropriate digestion of nutrients.