Multigenerational effects of dietary fat carcinogenesis in mice

The possibility of multigenerational transmission of a carcinogenic effect from exposure to a maternal diet high in fat was tested in mice. Diets with 2.6 or 29% fat (by weight) were fed to strain CD-1 mice during pregnancy. The female offspring were raised on a control diet (10% fat), mated, and co...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1997-10, Vol.57 (19), p.4162-4163
Main Authors: WALKER, B. E, KURTH, L. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Dietary Fats - toxicity
Female
Foods and miscellaneous
Genital Neoplasms, Female - chemically induced
Genital Neoplasms, Female - genetics
Hypothalamus - embryology
Hypothalamus - pathology
Maternal Exposure
Medical sciences
Mice
Mice, Inbred Strains
Neoplasm Metastasis
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - genetics
Pituitary Neoplasms - chemically induced
Pituitary Neoplasms - genetics
Pregnancy
Tumors
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Summary:The possibility of multigenerational transmission of a carcinogenic effect from exposure to a maternal diet high in fat was tested in mice. Diets with 2.6 or 29% fat (by weight) were fed to strain CD-1 mice during pregnancy. The female offspring were raised on a control diet (10% fat), mated, and continued on the control diet through pregnancy. Their female offspring were raised to terminal illness and autopsied. The total number of reproductive system tumors, pituitary tumors, and metastases was increased in the offspring with ancestral exposure to high dietary fat but to a lesser extent than had been reported previously for direct prenatal exposure to high maternal dietary fat. Because previous work has given evidence against germ cell transmission, a hypothesis based on a maternal effect was offered to explain the multigenerational carcinogenesis. These results have implications for epidemiological studies.
ISSN:0008-5472
1538-7445