Overexpression of p53 predicts shorter survival in diffuse type gastric cancer

Background It has been suggested that p53 plays an important part in gastric carcinogenesis but the data remain inconclusive. Methods Alteration of the tumour suppressor gene p53 was prospectively investigated by immunohistochemistry in 168 primary gastric cancers. Results Positive staining, indicat...

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Published in:British journal of surgery 1998-08, Vol.85 (8), p.1138-1142
Main Authors: Lee, W.-J., Shun, C.-T., Hong, R.-L., Wu, M.-S., Chang, K.-J., Chen, K.-M.
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - surgery
Adult
Aged
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression Regulation, Neoplastic
Genes, p53 - genetics
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Multivariate Analysis
Mutation
Prognosis
Prospective Studies
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumor Suppressor Protein p53 - metabolism
Tumors
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Summary:Background It has been suggested that p53 plays an important part in gastric carcinogenesis but the data remain inconclusive. Methods Alteration of the tumour suppressor gene p53 was prospectively investigated by immunohistochemistry in 168 primary gastric cancers. Results Positive staining, indicative of gene mutations, was detected in 34 tumours (20·2 per cent). No correlation was observed between expression of p53 and various clinicopathological factors, including age, sex, tumour site, gross type, tumour size, depth of invasion, lymph node metastases, distant metastases, and tumour node metastasis stage. However, p53 overexpression was different between intestinal and diffuse type gastric cancer. Survival analysis revealed a significant survival disadvantage of p53 expression in diffuse type gastric cancer (P = 0·039) but not in the intestinal type. Multivariate analysis of all 168 patients revealed that independent predictors of recurrent disease included age, invasion depth and nodal involvement but not p53 expression. Conclusion The presence of p53 overexpression may identify a subset of more aggressive tumours with a poor prognosis in diffuse type gastric cancer. © 1998 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.1365-2168.1998.00712.x