Dynamics of lung collapse and recruitment during prolonged breathing in porcine lung injury

Departments of 1  Clinical Physiology, 2  Anesthesiology, and 3  Diagnostic Radiology, University of Uppsala, Uppsala 75185, Sweden Oleic acid (OA) injection, lung lavage, and endotoxin infusion are three commonly used methods to induce experimental lung injury. The dynamics of lung collapse and rec...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1998-10, Vol.85 (4), p.1533-1543
Main Authors: Neumann, Peter, Berglund, Jan Erik, Mondejar, Enrique Fernandez, Magnusson, Anders, Hedenstierna, Goran
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Apnea
Biological and medical sciences
Blood Pressure
Cardiac Output
Comparative studies
Endotoxins - toxicity
Escherichia coli
Hemodynamics - physiology
Injuries
Lipopolysaccharides - toxicity
Lung - diagnostic imaging
Lung - physiopathology
Lung Injury
Lungs
Medical imaging
Medical procedures
Medical sciences
Oleic Acid - toxicity
Oxygen - blood
Pneumology
Positive-Pressure Respiration
Pulmonary Atelectasis - physiopathology
Pulmonary Edema - chemically induced
Pulmonary Edema - physiopathology
Pulmonary Wedge Pressure
Respiratory Mechanics - physiology
Respiratory system : syndromes and miscellaneous diseases
Swine
Therapeutic Irrigation
Tomography, X-Ray Computed
Vascular Resistance
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Summary:Departments of 1  Clinical Physiology, 2  Anesthesiology, and 3  Diagnostic Radiology, University of Uppsala, Uppsala 75185, Sweden Oleic acid (OA) injection, lung lavage, and endotoxin infusion are three commonly used methods to induce experimental lung injury. The dynamics of lung collapse and recruitment in these models have not been studied, although knowledge of this is desirable to establish ventilatory techniques that keep the lungs open. We measured lung density by computed tomography during breath-holding procedures. Lung injury was induced with OA, lung lavage, or endotoxin in groups of six mechanically ventilated pigs. After a stabilization period, repetitive computed tomography scans of the same slice were obtained during prolonged expirations with and without positive end-expiratory pressure and during prolonged inspirations after 5 and 30 s of expiration. Lung collapse and recruitment occurred mainly within the first 4 s of breath-holding procedures in all three lung injury models, and some collapse and recruitment occurred even within 0.6 s. OA-injured lungs were significantly more unstable than lungs injured by bronchoalveolar lavage or endotoxin infusion. In this experimental setting, expiration times
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1998.85.4.1533