Effects on the hemostatic system and liver function in relation to Implanon ® and Norplant ® : A prospective randomized clinical trial

In this prospective randomized clinical trial, two long-term contraceptive implants were studied with respect to hemostasis and liver function in 86 healthy young women. The two implants used were Implanon®, containing the progestagen etonogestrel (the biologically active metabolite of desogestrel)...

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Bibliographic Details
Published in:Contraception (Stoneham) 1998-08, Vol.58 (2), p.93-98
Main Authors: Egberg, Nils, van Beek, Agaath, Gunnervik, Christina, Hulkko, Seppo, Hirvonen, Erkki, Larsson-Cohn, Ulf, Bennink, HerjanCoelingh
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Contraceptive Agents, Female - adverse effects
contraceptive implant
Desogestrel
etonogestrel/3-ketodesogestrel
Female
Gynecology. Andrology. Obstetrics
hemostasis
Hemostasis - drug effects
Humans
Implanon
levonorgestrel
Levonorgestrel - adverse effects
Liver - drug effects
liver function
Liver Function Tests
Medical sciences
Norplant
Other methods of contraception. Sterilization
Progesterone Congeners - adverse effects
Prospective Studies
Vinyl Compounds - adverse effects
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Summary:In this prospective randomized clinical trial, two long-term contraceptive implants were studied with respect to hemostasis and liver function in 86 healthy young women. The two implants used were Implanon®, containing the progestagen etonogestrel (the biologically active metabolite of desogestrel) and Norplant®, the implant containing the progestagen levonorgestrel. The results of the trial showed that both implants had similar small effects on the hemostatic system that are not suggestive of a tendency towards thrombosis. The effect on liver function was characterized by increases in total bilirubin and γ-glutamyl transferase and decreases in alanine aminotransferase and aspartate aminotransferase.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(98)00070-5