Carbon monoxide and cyanide as intrinsic ligands to iron in the active site of [NiFe]-hydrogenases. NiFe(CN)2CO, Biology's way to activate H2

Infrared-spectroscopic studies on the [NiFe]-hydrogenase of Chromatium vinosum-enriched in 15N or 13C, as well as chemical analyses, show that this enzyme contains three non-exchangeable, intrinsic, diatomic molecules as ligands to the active site, one carbon monoxide molecule and two cyanide groups...

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Bibliographic Details
Published in:The Journal of biological chemistry 1999-02, Vol.274 (6), p.3331
Main Authors: Pierik, A J, Roseboom, W, Happe, R P, Bagley, K A, Albracht, S P
Format: Article
Language:English
Subjects:
Binding Sites
Carbon Isotopes
Carbon Monoxide - metabolism
Chromatium - enzymology
Cyanides - metabolism
Electron Spin Resonance Spectroscopy
Hydrogen - metabolism
Hydrogenase - metabolism
Iron - metabolism
Ligands
Nitrogen Isotopes
Spectroscopy, Fourier Transform Infrared
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