Population-Based Analysis of National Comprehensive Cancer Network (NCCN) Guideline Adherence for Patients with Anal Squamous Cell Carcinoma in California

We analyzed adherence to the National Comprehensive Cancer Network treatment guidelines for anal squamous cell carcinoma in California and the associated impacts on survival. This was a retrospective study of patients in the California Cancer Registry aged 18 to 79 years with recent diagnoses of ana...

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Bibliographic Details
Published in:Cancers 2023-02, Vol.15 (5), p.1465
Main Authors: Kumar, Priyanka, Del Rosario, Michael, Chang, Jenny, Ziogas, Argyrios, Jafari, Mehraneh D, Bristow, Robert E, Tanjasiri, Sora Park, Zell, Jason A
Format: Article
Language:English
Subjects:
Age
Anal cancer
Analysis
Cancer
Cancer therapies
Care and treatment
Distribution
Hispanic people
Human papillomavirus
Patient compliance
Patient outcomes
Patients
Radiation
Regression analysis
Sex
Socioeconomic factors
Squamous cell carcinoma
Surveillance
Survival analysis
Tumors
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Summary:We analyzed adherence to the National Comprehensive Cancer Network treatment guidelines for anal squamous cell carcinoma in California and the associated impacts on survival. This was a retrospective study of patients in the California Cancer Registry aged 18 to 79 years with recent diagnoses of anal squamous cell carcinoma. Predefined criteria were used to determine adherence. Adjusted odds ratios and 95% confidence intervals were estimated for those receiving adherent care. Disease-specific survival (DSS) and overall survival (OS) were examined with a Cox proportional hazards model. 4740 patients were analyzed. Female sex was positively associated with adherent care. Medicaid status and low socioeconomic status were negatively associated with adherent care. Non-adherent care was associated with worse OS (Adjusted HR 1.87, 95% CI = 1.66, 2.12, < 0.0001). DSS was worse in patients receiving non-adherent care (Adjusted HR 1.96, 95% CI = 1.56, 2.46, < 0.0001). Female sex was associated with improved DSS and OS. Black race, Medicare/Medicaid, and low socioeconomic status were associated with worse OS. Male patients, those with Medicaid insurance, or those with low socioeconomic status are less likely to receive adherent care. Adherent care was associated with improved DSS and OS in anal carcinoma patients.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15051465