Indications of vascular endothelial cell dysfunction in systemic lupus erythematosus

Fibrinolytic and other factors have been measured in 73 patients with systemic lupus erythematosus or related conditions to determine whether clinical thrombosis, a common feature of these disorders, is associated with defective fibrinolysis. Twenty five of 72 (35%) patients, compared with two of 22...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1987-10, Vol.46 (10), p.741-745
Main Authors: Byron, M A, Allington, M J, Chapel, H M, Mowat, A G, Cederholm-Williams, S A
Format: Article
Language:English
Subjects:
Adult
Antigens - analysis
Biological and medical sciences
Endothelium, Vascular - metabolism
Female
Fibrinolysis
Fibronectins - blood
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - metabolism
Male
Medical sciences
Plasminogen Activators - blood
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Thrombosis - blood
von Willebrand Factor - immunology
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Summary:Fibrinolytic and other factors have been measured in 73 patients with systemic lupus erythematosus or related conditions to determine whether clinical thrombosis, a common feature of these disorders, is associated with defective fibrinolysis. Twenty five of 72 (35%) patients, compared with two of 22 (9%) controls, showed a low level of plasminogen activator activity in response to venous occlusion, suggesting decreased fibrinolytic potential. In addition, mean plasma levels of von Willebrand factor antigen and fibronectin were markedly raised in the patients (mean (SD) 384.5 (277)% and 727 (436) mg/l respectively) compared with healthy controls (100 (50)% and 306 (65) mg/l). These data suggest a degree of endothelial cell dysfunction. No clear correlation was found between a history of thrombosis and any plasma factor measured, except for prolongation of clotting tests suggestive of the 'lupus anticoagulant'.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.46.10.741