Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation

This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients. This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) between Novemb...

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Bibliographic Details
Published in:Ultrasonography 2023-04, Vol.42 (2), p.286-296
Main Authors: Lee, Yoon Seong, Lee, Seunghyun, Choi, Young Hun, Cho, Yeon Jin, Lee, Seul Bi, Cheon, Jung-Eun, Hong, Kyung Taek, Kang, Hyoung Jin
Format: Article
Language:English
Subjects:
Ascites
Chemotherapy
Disease
elasticity imaging techniques
Gallbladder
hematopoietic stem cell transplantation
hepatic veno-occlusive disease
Hypertension
Laboratories
Liver
Original
Patients
Pediatrics
Software
Stem cell transplantation
Ultrasonic imaging
ultrasonography
Veins & arteries
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Summary:This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients. This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) between November 2019 and January 2021. All 34 patients (8.7±5.0 years) were examined using 2D-SWE for an initial diagnosis. A subgroup analysis was performed using the data from follow-up examinations of patients diagnosed with VOD. The characteristics of the initial VOD diagnosis were compared with the longitudinal changes observed in VOD patients who underwent multiple ultrasound examinations. In total, 19 patients were diagnosed with VOD at 17.6±9.4 days after HSCT. All VOD patients showed hepatomegaly, ascites, and gallbladder wall thickening. Liver stiffness was higher in VOD patients than in non-VOD patients (12.4±1.1 vs. 6.3±0.8 kPa, P
ISSN:2288-5919
2288-5943
DOI:10.14366/usg.22107