The contralateral effects of anticipated stimuli on brain activity measured by ERP and fMRI

• Published in: Psychophysiology 2023-03, Vol.60 (3), p.e14189-n/a
• Main Authors: Ohgami, Yoshimi, Kotani, Yasunori, Yoshida, Nobukiyo, Akai, Hiroyuki, Kunimatsu, Akira, Kiryu, Shigeru, Inoue, Yusuke
• Format: Article
• Language: English
• Subjects: anticipation; Auditory stimuli; Brain - physiology; Brain Mapping; Dominance; dorsal anterior insula; Event-related potentials; Evoked Potentials - physiology; Experiments; Functional Laterality - physiology; Functional magnetic resonance imaging; Hearing; hemispatial neglect; hemisphere difference; Hemispheric laterality; Humans; Magnetic Resonance Imaging; Neuroimaging; Original; Sensory integration; stimulus‐preceding negativity; Visual stimuli; von Economo neuron
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.14189

The present study examined the effects of unilateral stimulus presentation on the right hemisphere preponderance of the stimulus‐preceding negativity (SPN) in the event‐related potential (ERP) experiment, and aimed to elucidate whether unilateral stimulus presentation affected activations in the bilateral anterior insula in the functional magnetic resonance imaging (fMRI) experiment. Separate fMRI and ERP experiments were conducted using visual and auditory stimuli by manipulating the position of stimulus presentation (left side or right side) with the time estimation task. The ERP experiment revealed a significant right hemisphere preponderance during left stimulation and no laterality during the right stimulation. The fMRI experiment revealed that the left anterior insula was activated only in the right stimulation of auditory and visual stimuli whereas the right anterior insula was activated by both left and right stimulations. The visual condition retained a contralateral dominance, but the auditory condition showed a right hemisphere dominance in a localized area. The results of this study indicate that the SPN reflects perceptual anticipation, and also that the anterior insula is involved in its occurrence. The underlying neural mechanisms of the right hemisphere dominance in attention allocation to hemispaces that causes a hemispatial neglect are still unclear. Our study added a new finding that the right anterior insula plays a pivotal role for the right hemisphere dominance by showing congruent results of both ERP and fMRI experiments.