Frailty and affective disorders throughout adult life: A 5‐year follow‐up of the Lifelines Cohort Study

Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the cou...

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Published in:Journal of the American Geriatrics Society (JAGS) 2022-12, Vol.70 (12), p.3424-3435
Main Authors: Borges, Marcus K., Jeuring, Hans W., Marijnissen, Radboud M., Munster, Barbara C., Aprahamian, Ivan, Brink, Rob H. S., Hoogendijk, Emiel O., Oude Voshaar, Richard C.
Format: Article
Language:English
Subjects:
Affective disorders
Aged
Aging
Anxiety
anxiety disorder
Anxiety disorders
Clinical Investigation
Clinical Investigations
Cohort analysis
Cohort Studies
depressive disorder
Epidemiology
Follow-Up Studies
Frail Elderly - psychology
Frailty
Frailty - epidemiology
Frailty - psychology
Humans
Mental disorders
Middle Aged
Mood Disorders - epidemiology
Older people
Population studies
Prospective Studies
prospective study
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Summary:Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty. Methods Lifelines, a prospective population‐based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60‐item frailty index (FI) at baseline and a 35‐item FI at baseline and 5‐year follow‐up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM‐IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (
ISSN:0002-8614
1532-5415
1532-5415
DOI:10.1111/jgs.18021