Frailty and affective disorders throughout adult life: A 5‐year follow‐up of the Lifelines Cohort Study

Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the cou...

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Published in:Journal of the American Geriatrics Society (JAGS) 2022-12, Vol.70 (12), p.3424-3435
Main Authors: Borges, Marcus K., Jeuring, Hans W., Marijnissen, Radboud M., Munster, Barbara C., Aprahamian, Ivan, Brink, Rob H. S., Hoogendijk, Emiel O., Oude Voshaar, Richard C.
Format: Article
Language:English
Subjects:
Affective disorders
Aged
Aging
Anxiety
anxiety disorder
Anxiety disorders
Clinical Investigation
Clinical Investigations
Cohort analysis
Cohort Studies
depressive disorder
Epidemiology
Follow-Up Studies
Frail Elderly - psychology
Frailty
Frailty - epidemiology
Frailty - psychology
Humans
Mental disorders
Middle Aged
Mood Disorders - epidemiology
Older people
Population studies
Prospective Studies
prospective study
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container_issue 12
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container_title Journal of the American Geriatrics Society (JAGS)
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creator Borges, Marcus K.
Jeuring, Hans W.
Marijnissen, Radboud M.
Munster, Barbara C.
Aprahamian, Ivan
Brink, Rob H. S.
Hoogendijk, Emiel O.
Oude Voshaar, Richard C.
description Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty. Methods Lifelines, a prospective population‐based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60‐item frailty index (FI) at baseline and a 35‐item FI at baseline and 5‐year follow‐up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM‐IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (
doi_str_mv 10.1111/jgs.18021
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S. ; Hoogendijk, Emiel O. ; Oude Voshaar, Richard C.</creator><creatorcontrib>Borges, Marcus K. ; Jeuring, Hans W. ; Marijnissen, Radboud M. ; Munster, Barbara C. ; Aprahamian, Ivan ; Brink, Rob H. S. ; Hoogendijk, Emiel O. ; Oude Voshaar, Richard C.</creatorcontrib><description>Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty. Methods Lifelines, a prospective population‐based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60‐item frailty index (FI) at baseline and a 35‐item FI at baseline and 5‐year follow‐up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM‐IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (&lt;60 years) and older adults (≥60 years). Results The FI was associated with the onset of a depressive disorder (younger adults: odds ratio [OR] = 1.12; 95% confidence interval [CI] 1.11–1.13; older adults: OR = 1.13; 95% CI 1.09–1.16) as well as any anxiety disorder (younger adults: OR = 1.10; 95% CI 1.09–1.10; older adults: OR = 1.07; 95% CI 1.04–1.09). The other way around, depressive disorder and anxiety disorders were associated with an accelerated increase of frailty over time (depressive disorder: younger adults: beta [β] = 0.03, p &lt; 0.001; older adults: β = 0.04, p &lt; 0.001; and any anxiety disorder: younger adults: β = 0.02, p &lt; 0.001; older adults: β = 0.01, p &lt; 0.142), although the effect of anxiety disorders was less equivocal among older adults. Conclusions Affective disorders are reciprocally related to frailty. Results with respect to the impact of anxiety disorders on frailty suggest most impact at lower levels of frailty. Our results might imply that interventions to slow biological aging should be broadened towards younger and middle‐aged people as well as non‐frail older patients. To develop targeted treatment, future clinical and epidemiologic studies on the underlying pathways of this bidirectional association are needed.</description><identifier>ISSN: 0002-8614</identifier><identifier>ISSN: 1532-5415</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.18021</identifier><identifier>PMID: 36054011</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Affective disorders ; Aged ; Aging ; Anxiety ; anxiety disorder ; Anxiety disorders ; Clinical Investigation ; Clinical Investigations ; Cohort analysis ; Cohort Studies ; depressive disorder ; Epidemiology ; Follow-Up Studies ; Frail Elderly - psychology ; Frailty ; Frailty - epidemiology ; Frailty - psychology ; Humans ; Mental disorders ; Middle Aged ; Mood Disorders - epidemiology ; Older people ; Population studies ; Prospective Studies ; prospective study</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2022-12, Vol.70 (12), p.3424-3435</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.</rights><rights>2022 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4441-ec1a8c44034ed8b3577473cb075825ab407554b7a47922254f6884b890f6689f3</citedby><cites>FETCH-LOGICAL-c4441-ec1a8c44034ed8b3577473cb075825ab407554b7a47922254f6884b890f6689f3</cites><orcidid>0000-0003-0259-7480 ; 0000-0003-3806-7895 ; 0000-0001-9660-5108 ; 0000-0003-1501-4774 ; 0000-0002-0131-0735 ; 0000-0001-6056-7795</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36054011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borges, Marcus K.</creatorcontrib><creatorcontrib>Jeuring, Hans W.</creatorcontrib><creatorcontrib>Marijnissen, Radboud M.</creatorcontrib><creatorcontrib>Munster, Barbara C.</creatorcontrib><creatorcontrib>Aprahamian, Ivan</creatorcontrib><creatorcontrib>Brink, Rob H. S.</creatorcontrib><creatorcontrib>Hoogendijk, Emiel O.</creatorcontrib><creatorcontrib>Oude Voshaar, Richard C.</creatorcontrib><title>Frailty and affective disorders throughout adult life: A 5‐year follow‐up of the Lifelines Cohort Study</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty. Methods Lifelines, a prospective population‐based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60‐item frailty index (FI) at baseline and a 35‐item FI at baseline and 5‐year follow‐up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM‐IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (&lt;60 years) and older adults (≥60 years). Results The FI was associated with the onset of a depressive disorder (younger adults: odds ratio [OR] = 1.12; 95% confidence interval [CI] 1.11–1.13; older adults: OR = 1.13; 95% CI 1.09–1.16) as well as any anxiety disorder (younger adults: OR = 1.10; 95% CI 1.09–1.10; older adults: OR = 1.07; 95% CI 1.04–1.09). The other way around, depressive disorder and anxiety disorders were associated with an accelerated increase of frailty over time (depressive disorder: younger adults: beta [β] = 0.03, p &lt; 0.001; older adults: β = 0.04, p &lt; 0.001; and any anxiety disorder: younger adults: β = 0.02, p &lt; 0.001; older adults: β = 0.01, p &lt; 0.142), although the effect of anxiety disorders was less equivocal among older adults. Conclusions Affective disorders are reciprocally related to frailty. Results with respect to the impact of anxiety disorders on frailty suggest most impact at lower levels of frailty. Our results might imply that interventions to slow biological aging should be broadened towards younger and middle‐aged people as well as non‐frail older patients. 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S.</creatorcontrib><creatorcontrib>Hoogendijk, Emiel O.</creatorcontrib><creatorcontrib>Oude Voshaar, Richard C.</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library website</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borges, Marcus K.</au><au>Jeuring, Hans W.</au><au>Marijnissen, Radboud M.</au><au>Munster, Barbara C.</au><au>Aprahamian, Ivan</au><au>Brink, Rob H. S.</au><au>Hoogendijk, Emiel O.</au><au>Oude Voshaar, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frailty and affective disorders throughout adult life: A 5‐year follow‐up of the Lifelines Cohort Study</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2022-12</date><risdate>2022</risdate><volume>70</volume><issue>12</issue><spage>3424</spage><epage>3435</epage><pages>3424-3435</pages><issn>0002-8614</issn><issn>1532-5415</issn><eissn>1532-5415</eissn><abstract>Background Frailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty. Methods Lifelines, a prospective population‐based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60‐item frailty index (FI) at baseline and a 35‐item FI at baseline and 5‐year follow‐up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM‐IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (&lt;60 years) and older adults (≥60 years). Results The FI was associated with the onset of a depressive disorder (younger adults: odds ratio [OR] = 1.12; 95% confidence interval [CI] 1.11–1.13; older adults: OR = 1.13; 95% CI 1.09–1.16) as well as any anxiety disorder (younger adults: OR = 1.10; 95% CI 1.09–1.10; older adults: OR = 1.07; 95% CI 1.04–1.09). The other way around, depressive disorder and anxiety disorders were associated with an accelerated increase of frailty over time (depressive disorder: younger adults: beta [β] = 0.03, p &lt; 0.001; older adults: β = 0.04, p &lt; 0.001; and any anxiety disorder: younger adults: β = 0.02, p &lt; 0.001; older adults: β = 0.01, p &lt; 0.142), although the effect of anxiety disorders was less equivocal among older adults. Conclusions Affective disorders are reciprocally related to frailty. Results with respect to the impact of anxiety disorders on frailty suggest most impact at lower levels of frailty. Our results might imply that interventions to slow biological aging should be broadened towards younger and middle‐aged people as well as non‐frail older patients. To develop targeted treatment, future clinical and epidemiologic studies on the underlying pathways of this bidirectional association are needed.</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>36054011</pmid><doi>10.1111/jgs.18021</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0259-7480</orcidid><orcidid>https://orcid.org/0000-0003-3806-7895</orcidid><orcidid>https://orcid.org/0000-0001-9660-5108</orcidid><orcidid>https://orcid.org/0000-0003-1501-4774</orcidid><orcidid>https://orcid.org/0000-0002-0131-0735</orcidid><orcidid>https://orcid.org/0000-0001-6056-7795</orcidid><oa>free_for_read</oa></addata></record>
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subjects Affective disorders
Aged
Aging
Anxiety
anxiety disorder
Anxiety disorders
Clinical Investigation
Clinical Investigations
Cohort analysis
Cohort Studies
depressive disorder
Epidemiology
Follow-Up Studies
Frail Elderly - psychology
Frailty
Frailty - epidemiology
Frailty - psychology
Humans
Mental disorders
Middle Aged
Mood Disorders - epidemiology
Older people
Population studies
Prospective Studies
prospective study
title Frailty and affective disorders throughout adult life: A 5‐year follow‐up of the Lifelines Cohort Study
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