The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity

Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, m...

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Bibliographic Details
Published in:Nutrients 2023-03, Vol.15 (7), p.1723
Main Authors: Colangeli, Luca, Escobar Marcillo, David Israel, Simonelli, Valeria, Iorio, Egidio, Rinaldi, Tommaso, Sbraccia, Paolo, Fortini, Paola, Guglielmi, Valeria
Format: Article
Language:English
Subjects:
Adenosine
Adipocytes
Adipogenesis
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Angiogenesis
Atherosclerosis
Body fat
Changing environments
Chronic illnesses
Cold
Complications
Energy
Energy Metabolism
Environmental changes
Gastrointestinal Microbiome - physiology
Glucose
Histology
Homeostasis
Humans
Hyperplasia
Insulin resistance
Intestinal microflora
Lipids
Metabolic disorders
Metabolism
Metabolites
Microbiota
Microorganisms
Mitochondria
Mitochondria - metabolism
Molecular biology
Obesity
Obesity - metabolism
Organelles
Review
Thermogenesis
Thermogenesis - physiology
Tomography
Weight control
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Summary:Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, mitochondria, the intracellular organelles that orchestrate energy production and undergo highly dynamic adaptive changes in response to changing environments, have emerged as crucial regulators of both white (WAT) and brown adipose tissue (BAT) metabolism and function. Given that the gut microbiota and its metabolites are able to regulate host metabolism, adipogenesis, WAT inflammation, and thermogenesis, we hypothesize that their frequently observed dysregulation in obesity could affect AT metabolism by exerting direct and indirect effects on AT mitochondria. By collecting and revising the current evidence on the connections between gut microbiota and AT mitochondria in obesity, we gained insights into the molecular biology of their hitherto largely unexplored crosstalk, tracing how gut microbiota may regulate AT mitochondrial function.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15071723