A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentra...

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Bibliographic Details
Published in:Epigenetics 2023-12, Vol.18 (1), p.2202835-2202835
Main Authors: Monasso, Giulietta S., Hoang, Thanh T., Mancano, Giulia, Fernández-Barrés, Sílvia, Dou, John, Jaddoe, Vincent W.V., Page, Christian M., Johnson, Laura, Bustamante, Mariona, Bakulski, Kelly M., Håberg, Siri E., Ueland, Per M., Battram, Thomas, Merid, Simon K., Melén, Erik, Caramaschi, Doretta, Küpers, Leanne K., Sunyer, Jordi, Nystad, Wenche, Heil, Sandra G., Schmidt, Rebecca J., Vrijheid, Martine, Sharp, Gemma C., London, Stephanie J., Felix, Janine F.
Format: Article
Language:English
Subjects:
Birth Weight - genetics
Child
cohort study
DNA Methylation
epidemiology
Epigenesis, Genetic
Epigenome
Female
Fetal Blood - metabolism
Humans
Infant, Newborn
meta-analysis
PACE consortium
Pregnancy
Research Paper
Vitamin B 12 - metabolism
Vitamin B12
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Summary:Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2023.2202835