Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease

Increased oxidative stress and neuroinflammation play a crucial role in the pathogenesis of Parkinson's disease (PD). In this study, the expression levels of 52 genes related to oxidative stress and inflammation were measured in peripheral blood mononuclear cells of the discovery cohort includi...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7095
Main Authors: Chang, Kuo-Hsuan, Liu, Chia-Hsin, Wang, Yi-Ru, Lo, Yen-Shi, Chang, Chun-Wei, Wu, Hsiu-Chuan, Chen, Chiung-Mei
Format: Article
Language:English
Subjects:
Apoptotic Protease-Activating Factor 1 - genetics
Cognition disorders
Cognitive Dysfunction
Development and progression
Genes
Humans
Inflammation
Leukocytes, Mononuclear
Macrophage Colony-Stimulating Factor - metabolism
Mental Status and Dementia Tests
Parkinson Disease - diagnosis
Pramipexole
Receptor Protein-Tyrosine Kinases - genetics
Receptors, Colony-Stimulating Factor - genetics
Up-Regulation
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Summary:Increased oxidative stress and neuroinflammation play a crucial role in the pathogenesis of Parkinson's disease (PD). In this study, the expression levels of 52 genes related to oxidative stress and inflammation were measured in peripheral blood mononuclear cells of the discovery cohort including 48 PD patients and 25 healthy controls. Four genes, including , , , and , were found to be upregulated in PD patients. The expression patterns of these genes were validated in a second cohort of 101 PD patients and 61 healthy controls. The results confirmed the upregulation of (PD: 0.34 ± 0.18, control: 0.26 ± 0.11, < 0.001) and (PD: 0.38 ± 0.12, control: 0.33 ± 0.10, = 0.005) in PD patients. The expression level of was correlated with the scores of the Unified Parkinson's Disease Rating Scale (UPDRS, r = 0.235, = 0.018) and 39-item PD questionnaire (PDQ-39, r = 0.250, = 0.012). The expression level of was negatively correlated with the scores of the mini-mental status examination (MMSE, r = -0.200, = 0.047) and Montréal Cognitive Assessment (MoCA, r = -0.226, = 0.023). These results highly suggest that oxidative stress biomarkers in peripheral blood may be useful in monitoring the progression of motor disabilities and cognitive decline in PD patients.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24087095