Acinetobacter baumannii Bacteriophage: Progress in Isolation, Genome Sequencing, Preclinical Research, and Clinical Application

Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen associated with serious clinical challenges owing to its rapidly increasing resistance to antibiotics. Due to their high host specificity and easy access to the natural environment, bacteriophages (phages) may serve as good antib...

Full description

Saved in:
Bibliographic Details
Published in:Current microbiology 2023-06, Vol.80 (6), p.199-199, Article 199
Main Authors: Li, Yanqi, Xiao, Shune, Huang, Guangtao
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - genetics
Anti-Bacterial Agents
Antibacterial agents
Antibiotic resistance
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Bacteriophages - genetics
Base Sequence
Biofilms
Biomedical and Life Sciences
Biotechnology
Chromosomes
Drug resistance
Gene sequencing
Genomes
Host specificity
Hydrogels
Infections
Life Sciences
Microbiology
Natural environment
Nosocomial infection
Phages
Plastic surgery
Pneumonia
Review
Review Article
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen associated with serious clinical challenges owing to its rapidly increasing resistance to antibiotics. Due to their high host specificity and easy access to the natural environment, bacteriophages (phages) may serve as good antibacterial agents. Phage therapy has been successfully used to treat antibiotic-resistant A. baumannii infections. As a fundamental step before phage therapy, the characterization and sequencing of A. baumannii phages have been well studied. Until October 2022, 132 A. baumannii phages have been sequenced and studied, with their genomes ranging from 4 to 234 kb, and we summarize the characterized and sequenced A. baumannii phages. This review is a current and short overview that does not go into detail on the A. baumannii phages. In addition, preclinical studies and clinical applications of A. baumannii phages are also included.
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-023-03295-z