Does obstructive sleep apnoea modulate cardiac autonomic function in paroxysmal atrial fibrillation?

• Published in: Journal of interventional cardiac electrophysiology 2023-06, Vol.66 (4), p.873-883
• Main Authors: Mohammadieh, Anna Mary, Dissanayake, Hasthi U., Sutherland, Kate, Ucak, Seren, De Chazal, Philip, Cistulli, Peter A.
• Format: Article
• Language: English
• Subjects: Aged; Apnea; Atrial Fibrillation; Autonomic Nervous System; Cardiac arrhythmia; Cardiology; Case-Control Studies; EKG; Female; Fibrillation; Frequency analysis; Frequency domain analysis; Heart - physiology; Heart rate; Heart Rate - physiology; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Modulation; NREM sleep; Parasympathetic nervous system; REM sleep; Sleep; Sleep apnea; Sleep Apnea, Obstructive; Sleep disorders; Steady state
• ISSN: 1572-8595; 1383-875X; 1572-8595
• DOI: 10.1007/s10840-022-01202-3

Purpose The autonomic nervous system may mediate acute apnoea–induced atrial fibrillation (AF). We compared cardiac autonomic function in paroxysmal atrial fibrillation (PAF) patients with and without obstructive sleep apnoea (OSA). Methods Case control study of 101 patients with PAF recruited at two tertiary centres. All patients underwent in-laboratory polysomnography. ECG signal demonstrating “steady state” sinus rhythm (i.e. with arrhythmic beats and respiratory events excluded) was included in the analysis. Cardiac autonomic function was assessed via measures of heart rate variability (HRV) and reported by sleep stage (REM vs Non-REM) for patients with and without OSA. Results Sixty-five (66.3%) of patients were male, mean age 61.5 ± 11.6 years, mean BMI 27.1 ± 4.3 kg/m 2 . Global measures of HRV (triangular index, total power) did not differ between PAF patients with and without OSA in either REM or non-REM sleep. Frequency-domain analysis during non-REM sleep in PAF patients with OSA showed increased cardiac parasympathetic modulation (HF-nu: 39.1 ± 15.7 vs 48.0 ± 14.6, p  = 0.008) and reduced cardiac sympathetic modulation (LF-nu 54.1 ± 19.7 vs 43.7 ± 18.0, p  = 0.012, LF/HF ratio: 2.1 ± 2.0 vs 1.2 ± 1.0, p  = 0.007). Results remained significant after adjusting for age, sex, and BMI (adjusted p values 0.024, 0.045 and 0.018 respectively). There were no differences in HRV parameters during REM sleep. Conclusions This is the first study of HRV in PAF patients with and without OSA. Our results indicate limited differences in HRV between groups. However, this work suggests a chronic increase in parasympathetic nervous modulation and relative reduction in sympathetic modulation in PAF patients with OSA during steady-state non-REM sleep.