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Role of Sex Hormones in Prevalent Kidney Diseases
Chronic kidney disease (CKD) is a constantly growing global health burden, with more than 840 million people affected worldwide. CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is...
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| Published in: | International journal of molecular sciences 2023-05, Vol.24 (9), p.8244 |
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| container_title | International journal of molecular sciences |
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| creator | Conte, Carolina Antonelli, Giulia Melica, Maria Elena Tarocchi, Mirko Romagnani, Paola Peired, Anna Julie |
| description | Chronic kidney disease (CKD) is a constantly growing global health burden, with more than 840 million people affected worldwide. CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. We report clinical and experimental findings on the role of sex hormones in the development of the disease and its progression to end-stage kidney disease. |
| doi_str_mv | 10.3390/ijms24098244 |
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CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. We report clinical and experimental findings on the role of sex hormones in the development of the disease and its progression to end-stage kidney disease.</description><subject>Androgens</subject><subject>Cardiovascular disease</subject><subject>Chronic kidney failure</subject><subject>Development and progression</subject><subject>Diabetes mellitus</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Disease Progression</subject><subject>End-stage renal disease</subject><subject>Epidemiology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gonadal Steroid Hormones</subject><subject>Hormone replacement therapy</subject><subject>Hormones, Sex</subject><subject>Humans</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Industrialized nations</subject><subject>Kidney</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic</subject><subject>Kidney transplants</subject><subject>Lupus</subject><subject>Lupus nephritis</subject><subject>Male</subject><subject>Males</subject><subject>Menopause</subject><subject>Nephritis</subject><subject>Nephrology</subject><subject>Oophorectomy</subject><subject>Ovaries</subject><subject>Physiology</subject><subject>Polycystic kidney</subject><subject>Public health</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Review</subject><subject>Sex hormones</subject><subject>Testosterone</subject><subject>Transgender persons</subject><subject>Womens health</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkUlLBDEQhYMo7jfP0uDFg6OVrTs5ibijoLicQyZdrRm6O5rMiP57M7iNIjkkJF-9Sr1HyAaFXc417PlRl5gArZgQc2SZCsYGAGU1P3NeIispjQAYZ1IvkiVe0UpqUS0TehNaLEJT3OJrcRZiF3pMhe-L64gvtsV-XFz4use34sgntAnTGllobJtw_XNfJfcnx3eHZ4PLq9Pzw4PLgRMKxoNS8tKWTkmAoWY1WHC6KakCKUqtUA2dE7UcVoKLhluBljInWa2YEsBYU_NVsv-h-zQZdli7_JVoW_MUfWfjmwnWm98vvX80D-HFUKCVpppmhe1PhRieJ5jGpvPJYdvaHsMkGaYolyXnQmd06w86CpPY5_mmFJMSBFU_1EN2xvi-Cbmxm4qag0oywbjikKndf6i8auy8y_42Pt__Ktj5KHAxpBSx-R6SgplmbGYzzvjmrDHf8Feo_B1ytp6n</recordid><startdate>20230504</startdate><enddate>20230504</enddate><creator>Conte, Carolina</creator><creator>Antonelli, Giulia</creator><creator>Melica, Maria Elena</creator><creator>Tarocchi, Mirko</creator><creator>Romagnani, Paola</creator><creator>Peired, Anna Julie</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1774-8088</orcidid><orcidid>https://orcid.org/0000-0001-9732-1369</orcidid><orcidid>https://orcid.org/0000-0002-7767-5116</orcidid></search><sort><creationdate>20230504</creationdate><title>Role of Sex Hormones in Prevalent Kidney Diseases</title><author>Conte, Carolina ; 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CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. 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| subjects | Androgens Cardiovascular disease Chronic kidney failure Development and progression Diabetes mellitus Diabetic Nephropathies - epidemiology Disease Progression End-stage renal disease Epidemiology Estrogens Female Gonadal Steroid Hormones Hormone replacement therapy Hormones, Sex Humans IgA nephropathy Immunoglobulin A Industrialized nations Kidney Kidney diseases Kidney Failure, Chronic Kidney transplants Lupus Lupus nephritis Male Males Menopause Nephritis Nephrology Oophorectomy Ovaries Physiology Polycystic kidney Public health Renal Insufficiency, Chronic - epidemiology Review Sex hormones Testosterone Transgender persons Womens health |
| title | Role of Sex Hormones in Prevalent Kidney Diseases |
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