Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation

• Published in: Neuroscience and biobehavioral reviews 2020-01, Vol.108, p.435-444
• Main Authors: Ahrens, Allison M., Ahmed, Omar J.
• Format: Article
• Language: English
• Subjects: Animals; Behavior, Addictive - etiology; Brain - metabolism; Brain - physiopathology; Disease Models, Animal; Disease Susceptibility; Goal-tracking; Humans; Incentive salience; Individual differences; Individuality; Motivation - physiology; Reinforcement; Reward; Sign-tracking; Sleep; Sleep Deprivation - complications; Substance-Related Disorders - etiology
• ISSN: 0149-7634; 1873-7528
• DOI: 10.1016/j.neubiorev.2019.11.007

•There is individual variation in the effects of sleep loss on reward circuitry.•This individual variation has been difficult to study in preclinical animal models.•There exists a Sign/Goal Tracker model of individual differences in cued motivation.•There is overlapping circuitry responsible for both sleep and ST/GT behavior.•ST/GT model can be used to study individual variation in sleep-reward interactions. Individuals differ widely in their drug-craving behaviors. One reason for these differences involves sleep. Sleep disturbances lead to an increased risk of substance use disorders and relapse in only some individuals. While animal studies have examined the impact of sleep on reward circuitry, few have addressed the role of individual differences in the effects of altered sleep. There does, however, exist a rodent model of individual differences in reward-seeking behavior: the sign/goal-tracker model of Pavlovian conditioned approach. In this model, only some rats show the key behavioral traits associated with addiction, including impulsivity and poor attentional control, making this an ideal model system to examine individually distinct sleep-reward interactions. Here, we describe how the limbic neural circuits responsible for individual differences in incentive motivation overlap with those involved in sleep-wake regulation, and how this model can elucidate the common underlying mechanisms. Consideration of individual differences in preclinical models would improve our understanding of how sleep interacts with motivational systems, and why sleep deprivation contributes to addiction in only select individuals.