The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning

Accumulating evidence suggests that α-synuclein plays a role in the pathophysiology of Alzheimer's disease (AD). This study examined whether α-synuclein level in cerebrospinal fluid (CSF) was associated with cognitive functioning among older adults. We also explored whether this relationship wa...

Full description

Saved in:
Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-02, Vol.78 (2), p.206-212
Main Authors: Dabiri, Sanaz, Ramírez Ruiz, Mara I, Jean-Louis, Girardin, Ntekim, Oyonumo E, Obisesan, Thomas O, Campbell, Alfonso L, Mwendwa, Denée T
Format: Article
Language:English
Subjects:
Age
Aged
alpha-Synuclein - cerebrospinal fluid
Alzheimer Disease - diagnosis
Alzheimer's disease
Biomarkers
Biomarkers - cerebrospinal fluid
Cerebrospinal fluid
Cognition
Cognitive ability
Cognitive Dysfunction - diagnosis
Cross-Sectional Studies
Cytokines
Female
Humans
Inflammation
Interleukin 6
Male
Medical diagnosis
Neurodegenerative diseases
Neuroimaging
Neuropsychological Tests
Older people
Prospective Studies
Synuclein
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Tumor necrosis factor-α
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accumulating evidence suggests that α-synuclein plays a role in the pathophysiology of Alzheimer's disease (AD). This study examined whether α-synuclein level in cerebrospinal fluid (CSF) was associated with cognitive functioning among older adults. We also explored whether this relationship was mediated by proinflammatory cytokines TNF-α and IL-6, along with sIL-6R and vascular endothelial growth factor (VEGF). Using a cross-sectional Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 148) sample, we examined the relationship between α-synuclein and participants' performance on Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog 13) at baseline. Mediation analyses were utilized, adjusting for age, education, APOEe4, and Geriatric Depression Scale scores. All biological markers were measured in CSF. Participants in the current sample were 58.3% males, 41.7% females, and Caucasian (95.5%); their average education and age were 15.5 (standard deviation [SD] = 2.97) and 74.4 (SD = 7.51) years, respectively. Higher accumulation of α-synuclein was associated with poorer MMSE scores (β = -0.41, standard error [SE] = 1.54, p 
ISSN:1079-5006
1758-535X
1758-535X
DOI:10.1093/gerona/glac217