Fucoidan-Containing, Low-Adhesive Siloxane Coatings for Medical Applications: Inhibition of Bacterial Growth and Biofilm Development

The deposition of low-adhesive siloxane coatings is a current trend for the non-toxic control of bacterial growth and biofilm formation. Total elimination of biofilm formation has not been reported so far. The aim of this investigation was to study the ability of a non-toxic, natural, biologically a...

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Bibliographic Details
Published in:Materials 2023-05, Vol.16 (10), p.3651
Main Authors: Vladkova, Todorka G, Staneva, Anna D, Avramova, Ivalina A, Ivanova, Iliana A, Gospodinova, Dilyana N
Format: Article
Language:English
Subjects:
Adhesives
Algae
Antibiotics
Antimicrobial agents
Antioxidants
Biofilms
Biological activity
Cell growth
Coatings
Coliforms
Contact angle
E coli
Escherichia coli
Growth
Infections
Investigations
Medical devices
Medical equipment
Methicillin
Physiological apparatus
Severe acute respiratory syndrome coronavirus 2
Silicon compounds
Silicones
Siloxanes
Spectrum analysis
Surface properties
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Summary:The deposition of low-adhesive siloxane coatings is a current trend for the non-toxic control of bacterial growth and biofilm formation. Total elimination of biofilm formation has not been reported so far. The aim of this investigation was to study the ability of a non-toxic, natural, biologically active substance, such as fucoidan, to inhibit bacterial growth on similar medical coatings. The fucoidan amount was varied, and its impact on the bioadhesion-influencing surface characteristics, as well as on bacterial cell growth, was investigated. The inclusion of up to 3-4 wt.% brown algae-derived fucoidan in the coatings increases their inhibitory effect, more significantly on the Gram-positive bacterium than on the Gram-negative bacterium . The biological activity of the studied siloxane coatings was ascribed to the formation of a low-adhesive, biologically active surface top layer consisting of siloxane oil and dispersed water-soluble fucoidan particles. This is the first report on the antibacterial activity of fucoidan-containing medical siloxane coatings. The experimental results give reason to expect that relevantly selected, natural biologically active substances can be efficient in the non-toxic control of bacterial growth on medical devices and, as a result, medical device-associated infections.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma16103651