L-arginine-induced pancreatitis aggravated by inhibiting Na+/Ca2+ exchanger 1

Na+/Ca2+ exchangers (NCX) are an exchange transporter of Na+ and Ca2+ ions on the plasma membrane. There are three types of NCX: NCX1, NCX2, and NCX3. We have been working for many years to understand the role of NCX1 and NCX2 in gastrointestinal motility. In this study, we focused on the pancreas,...

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Published in:Journal of Veterinary Medical Science 2023, Vol.85(6), pp.657-666
Main Authors: ONO, Naoshige, HORIKOSHI, Joji, IZAWA, Takeshi, NISHIYAMA, Kazuhiro, TANAKA, Miyuu, KUWAMURA, Mitsuru, AZUMA, Yasu-Taka
Format: Article
Language:English
Subjects:
Arginine
Autophagy
Calcium
Gastric motility
Gastrointestinal tract
Homeostasis
Na+/Ca2+ exchanger
NCX1 protein
Pancreatitis
Pharmacology
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Summary:Na+/Ca2+ exchangers (NCX) are an exchange transporter of Na+ and Ca2+ ions on the plasma membrane. There are three types of NCX: NCX1, NCX2, and NCX3. We have been working for many years to understand the role of NCX1 and NCX2 in gastrointestinal motility. In this study, we focused on the pancreas, an organ closely related to the gastrointestinal tract, and used a mouse model of acute pancreatitis to investigate a possible role for NCX1 in the pathogenesis of pancreatitis. We characterized a model of acute pancreatitis induced by excessive doses of L-arginine. We administered the NCX1 inhibitor SEA0400 (1 mg/kg) 1 hr prior to L-arginine-induced pancreatitis and evaluated pathological changes. Mice treated with NCX1 inhibitors show exacerbation of the disease with decreased survival and increased amylase activity in response to L-arginine-induced experimental acute pancreatitis, and this exacerbation correlates with increased autophagy mediated by LC3B and p62. These results suggest that NCX1 has a role in regulating pancreatic inflammation and acinar cell homeostasis.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.22-0569