Cost-effectiveness of fixation versus arthroplasty for geriatric distal femur fractures

• Published in: Injury 2022-02, Vol.53 (2), p.661-668
• Main Authors: Brodke, Dane J., Devana, Sai K., Upfill-Brown, Alexander, Lee, Christopher
• Format: Article
• Language: English
• Subjects: Aged; Arthroplasty; Cost-Benefit Analysis; Cost-effectiveness analysis; Distal femur fracture; Distal femur replacement; Femoral Fractures - surgery; Femur - surgery; Fracture Fixation, Internal; Geriatric fractures; Humans; Quality of Life; Systematic review
• ISSN: 0020-1383; 1879-0267
• DOI: 10.1016/j.injury.2021.11.054

•Distal femur replacement (DFR) is an emerging alternative to internal fixation for geriatric distal femur fractures.•This systematic literature review revealed a higher rate of revision surgery and mortality for DFR relative to fixation.•Internal fixation is a more cost-effective treatment than DFR for geriatric distal femur fractures. Geriatric distal femur fractures are challenging to treat. The high mortality rate associated with a loss of mobility in this population has led some authors to compare distal femur fractures to femoral neck fractures with respect to the importance of rapidly regaining mobility in the geriatric population. Acute distal femur replacement has been advocated by some as a preferred treatment over internal fixation because arthroplasty may facilitate a more rapid return to a patient's baseline mobility level. The purpose of this study was to systematically review the literature on the costs and outcomes of fixation and arthroplasty in the geriatric distal femur fracture population and to employ decision modeling techniques to generate evidence-based treatment recommendations. A systematic literature review of clinical studies published since 2000 was conducted to synthesize the available data on outcomes, reoperation rates, and mortality rates after fixation or arthroplasty for distal femur fractures in patients with an average age greater than 70 years. A Markov decision analysis model was created. Costs, health state utilities, reoperation rates, and mortality rates were derived from the systematic literature review and publicly available data. The model was analyzed via probabilistic statistical analysis as well as sensitivity analyses with a willingness-to-pay threshold set at $100,000 per QALY and a 5-year time horizon. From a US societal perspective, fixation was associated with a greater quality of life benefit (2.44 QALYs vs. 2.34 QALYs) and lower cost ($25,556 vs. $65,536) compared with distal femur replacement for geriatric distal femur fractures. Probabilistic analysis demonstrated that 82 in 100 model outcomes favored fixation over arthroplasty and 18 in 100 model outcomes favored distal femur replacement. Sensitivity analyses demonstrated that this result was robust to small deviations in the cost and functional outcome variables in the model. Compared to distal femur replacement, ORIF is likely to be a more cost-effective treatment for distal femur fractures in the geriatric patient population, though this recommen