Corticosteroid-LABA inhalers increase phonation threshold pressure (PTP) and flow (PTF) in rabbits

This study examined the effects of a combination corticosteroid plus long-acting beta -adrenergic agonist inhaler (IC) on rabbit phonation. White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses o...

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Bibliographic Details
Published in:The Laryngoscope 2023-10, Vol.133 (10), p.2680-2686
Main Authors: Tanner, Kristine, Robison, Heidi J, Stevens, Maya Elena, Merrill, Ray M, Dromey, Christopher, Barkmeier-Kraemer, Julie, Christensen, M Ben
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adrenal Cortex Hormones
Animals
Fluticasone-Salmeterol Drug Combination
Laryngoscopy
Male
Nebulizers and Vaporizers
Phonation
Rabbits
Steroids
Voice Disorders
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Summary:This study examined the effects of a combination corticosteroid plus long-acting beta -adrenergic agonist inhaler (IC) on rabbit phonation. White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure (PTP; cmH O) and flow (PTF; L/min) were quantified. Repeated measures analysis of variance indicated significant differences between the experimental and control groups (p 
ISSN:0023-852X
1531-4995
1531-4995
DOI:10.1002/lary.30585