Higher frequency but similar recurrence rate of uveitis episodes in axial spondylarthritis compared to psoriatic arthritis. A multicentre retrospective study

• Published in: Rheumatology international 2023-11, Vol.43 (11), p.2081-2088
• Main Authors: Kougkas, Nikolaos, Magiouf, Konstantina, Gialouri, Chrysoula G., Evangelatos, Gerasimos, Pappa, Maria, Dimouli, Aikaterini, Iliopoulos, Alexios, Karmanakos, Anastasios, Dimitroulas, Theodoros, Tektonidou, Maria G., Sfikakis, Petros P., Fragoulis, George E.
• Format: Article
• Language: English
• Subjects: Medicine; Medicine & Public Health; Observational Research; Psoriatic arthritis; Rheumatology
• ISSN: 1437-160X; 0172-8172; 1437-160X
• DOI: 10.1007/s00296-023-05424-0

Background/Objective Data on risk factors predicting uveitis development in spondyloarthritis (SpA) is scarce. Our aim was to examine associations between demographic, clinical and/or laboratory characteristics of SpA with the occurrence and the course of uveitis, including ocular damage and recurrence rate. Methods Characteristics (at disease diagnosis and ever-present) from axSpA and Psoriatic arthritis (PsA) patients followed in 3 tertiary rheumatology-clinics were retrospectively recorded. Comparisons were made between patients with and without uveitis, as well as between those with uveitis-rate [episodes/year] above the median uveitis-rate in the whole cohort (“recurrent”-uveitis) and the remaining uveitis patients (“non-recurrent uveitis”). In multivariable models, age, gender and variables significantly different in univariate analyses were included. Results 264 axSpA and 369 PsA patients were enrolled. In axSpA, uveitis occurred in 11.7% and was associated with HLA-B27 (OR = 4.15, 95%CI 1.16–14.80, p  = 0.028) and ever-present peripheral arthritis (OR = 3.05 (1.10–8.41, p  = 0.031). In contrast, uveitis in PsA occurred only in 2.7% of patients and was associated with SpA family-history (OR = 6.35 (1.29–31.27), p  = 0.023) axial disease at diagnosis (OR = 5.61 [1.01–28.69], p  = 0.038) and disease duration (OR = 1.12 [1.04–1.21], p  = 0.004). Median uveitis recurrence rate was comparable between axSpA and PsA (0.205 and 0.285 episodes/year, respectively). No associations were found between recurrent uveitis and demographic/clinical/laboratory characteristics. Ocular damage (e.g. synechiae) was seen in 16.1% of axSpA and 30% of PsA patients, all of them with recurrent uveitis. Conclusion Uveitis occurred more commonly in axSpA than in PsA patients, while uveitis recurrence rate was similar. Permanent ocular damage may occur more often in PsA than axSpA.