Association between resistance to cerebrospinal fluid flow and cardiac-induced brain tissue motion for Chiari malformation type I

• Published in: Neuroradiology 2023-10, Vol.65 (10), p.1535-1543
• Main Authors: Mohsenian, Saeed, Ibrahimy, Alaaddin, Al Samman, Mohamad Motaz F., Oshinski, John N., Bhadelia, Rafeeque A., Barrow, Daniel L., Allen, Philip A., Amini, Rouzbeh, Loth, Francis
• Format: Article
• Language: English
• Subjects: Brain; Brain stem; Canals (anatomy); Cerebellum; Cerebrospinal fluid; Computational fluid dynamics; Computational neuroscience; Congenital defects; Fluid dynamics; Fluid flow; Heart; Hydrodynamics; Imaging; Magnetic resonance imaging; Medicine; Medicine & Public Health; Neural tube defects; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Radiology; Spinal Neuroradiology; Tissues; Vomiting
• ISSN: 0028-3940; 1432-1920; 1432-1920
• DOI: 10.1007/s00234-023-03207-9

Purpose Chiari malformation type I (CMI) patients have been independently shown to have both increased resistance to cerebrospinal fluid (CSF) flow in the cervical spinal canal and greater cardiac-induced neural tissue motion compared to healthy controls. The goal of this paper is to determine if a relationship exists between CSF flow resistance and brain tissue motion in CMI subjects. Methods Computational fluid dynamics (CFD) techniques were employed to compute integrated longitudinal impedance (ILI) as a measure of unsteady resistance to CSF flow in the cervical spinal canal in thirty-two CMI subjects and eighteen healthy controls. Neural tissue motion during the cardiac cycle was assessed using displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) technique. Results The results demonstrate a positive correlation between resistance to CSF flow and the maximum displacement of the cerebellum for CMI subjects ( r  = 0.75, p  = 6.77 × 10 −10 ) but not for healthy controls. No correlation was found between CSF flow resistance and maximum displacement in the brainstem for CMI or healthy subjects. The magnitude of resistance to CSF flow and maximum cardiac-induced brain tissue motion were not statistically different for CMI subjects with and without the presence of five CMI symptoms: imbalance, vertigo, swallowing difficulties, nausea or vomiting, and hoarseness. Conclusion This study establishes a relationship between CSF flow resistance in the cervical spinal canal and cardiac-induced brain tissue motion in the cerebellum for CMI subjects. Further research is necessary to understand the importance of resistance and brain tissue motion in the symptomatology of CMI.