An economic evaluation of first-line cryoballoon ablation vs antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from a U.S. Medicare perspective

• Published in: Heart rhythm O2 2023-09, Vol.4 (9), p.528-537
• Main Authors: Wazni, Oussama, Moss, Joe, Kuniss, Malte, Andrade, Jason, Chierchia, Gian Battista, Mealing, Stuart, Mburu, Waruiru, Sale, Alicia, Kaplon, Rachelle, Ismyrloglou, Eleni, Bromilow, Tom, Lane, Emily, Lewis, Damian, Reynolds, Matthew R.
• Format: Article
• Language: English
• Subjects: Ablation; Antiarrhythmic drug; Clinical; Cost-effectiveness; Cryoablation; Cryoballoon; Economic evaluation; Initial rhythm control; Paroxysmal atrial fibrillation; Pulmonary vein isolation
• ISSN: 2666-5018; 2666-5018
• DOI: 10.1016/j.hroo.2023.07.007

Three recent randomized controlled trials have demonstrated that, as an initial rhythm control strategy, first-line cryoballoon ablation (cryoablation) reduces atrial arrhythmia recurrence compared with antiarrhythmic drugs (AADs) in patients with symptomatic paroxysmal atrial fibrillation (PAF). The study sought to evaluate the cost-effectiveness of first-line cryoablation compared with first-line AADs for treating symptomatic PAF from a U.S. Medicare payer perspective. Individual patient-level data from 703 participants with PAF enrolled into the Cryo-FIRST (NCT01803438), STOP AF First (NCT03118518), and EARLY-AF (NCT02825979) trials were used to derive parameters for the cost-effectiveness model. The cost-effectiveness model used a hybrid decision tree and Markov structure. The decision tree had a 1-year time horizon and was used to inform the initial health state allocation in the first cycle of the Markov model. The Markov model used a 40-year time horizon (3-month cycle length). Health benefits were expressed in quality-adjusted life years (QALYs). Costs and benefits were discounted at 3% per year. Cryoablation was estimated to yield higher QALYs (+0.17) and higher costs (+$4274) per patient over a 40-year time horizon than AADs. Ultimately, this produced an average incremental cost-effectiveness ratio of $24,637 per QALY gained. Independent of initial treatment, individuals were expected to receive ∼1.2 ablations over a lifetime. There was a 45% relative reduction in time spent in atrial fibrillation health states for those initially treated with cryoablation compared with AADs. Initial rhythm control with first-line cryoballoon ablation is highly cost-effective compared with first-line AADs from a U.S. Medicare payer perspective.