Antibacterial and antibiofilm activities of ZIF-67

Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide. Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore, the discovery of new antibacterial and antibiofilm compounds is an issue of paramount importance to combat an...

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Bibliographic Details
Published in:Journal of antibiotics 2023-10, Vol.76 (10), p.603-612
Main Authors: Gallegos-Monterrosa, Ramses, Mendiola, Rodrigo Orozco, Nuñez, Yoselin, Auvynet, Constance, Kumar, Kesarla Mohan, Tang, Bin, Ruiz-Ortega, Leonardo I., Bustamante, Víctor H.
Format: Article
Language:English
Subjects:
13/106
13/2
14/28
631/326/22/1290
639/925/352
Animals
Anions
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
Bacteriology
Biofilms
Biological properties
Biomedical and Life Sciences
Bioorganic Chemistry
Cations
Cobalt
Cytotoxicity
Imidazoles - pharmacology
Life Sciences
Mammalian cells
Mammals
Medical equipment
Medicinal Chemistry
Metallography
Microbial Sensitivity Tests
Microbiology
Nanomaterials
Nanoparticles
Organic Chemistry
Organic compounds
Public health
Staphylococcus aureus
Staphylococcus infections
Toxicity
Virulence
Zeolites - pharmacology
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Summary:Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide. Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore, the discovery of new antibacterial and antibiofilm compounds is an issue of paramount importance to combat and prevent hard-to-treat bacterial infections. Zeolitic-imidazolate-frameworks (ZIFs) are metallo-organic compounds known to have various interesting chemical and biological applications, including antibacterial properties. In this study, we synthesized ZIF-67 nanoparticles, formed by imidazolate anions and cobalt cations, and found that they inhibit the growth of Acinetobacter baumannii , Pseudomonas aeruginosa , and Staphylococcus aureus . Sub-inhibitory concentrations of ZIF-67 were also able to significantly reduce the biomass of pre-established biofilms of these pathogenic bacteria. On the other hand, the ZIF-67 nanoparticles had null or low cytotoxicity in mammalian cells at those concentrations showing antibacterial or antibiofilm activities. Thus, our results reveal the potential of ZIF-67 nanoparticles to be used against pathogenic bacteria.
ISSN:0021-8820
1881-1469
1881-1469
DOI:10.1038/s41429-023-00637-8