Mitochondria Transplantation from Stem Cells for Mitigating Sarcopenia

Sarcopenia is defined as the age-related loss of muscle mass and function that can lead to prolonged hospital stays and decreased independence. It is a significant health and financial burden for individuals, families, and society as a whole. The accumulation of damaged mitochondria in skeletal musc...

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Bibliographic Details
Published in:Aging and disease 2023-10, Vol.14 (5), p.1700-1713
Main Authors: Tian, Xiulin, Pan, Mengxiong, Zhou, Mengting, Tang, Qiaomin, Chen, Miao, Hong, Wenwu, Zhao, Fangling, Liu, Kaiming
Format: Article
Language:English
Subjects:
B cells
Care and treatment
Diagnosis
Exercise
Force and energy
Health aspects
Mitochondria
Muscles
Patient compliance
Physical fitness
Physiological aspects
Review
Sarcopenia
Stem cell research
Stem cells
Transplantation
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Summary:Sarcopenia is defined as the age-related loss of muscle mass and function that can lead to prolonged hospital stays and decreased independence. It is a significant health and financial burden for individuals, families, and society as a whole. The accumulation of damaged mitochondria in skeletal muscle contributes to the degeneration of muscles with age. Currently, the treatment of sarcopenia is limited to improving nutrition and physical activity. Studying effective methods to alleviate and treat sarcopenia to improve the quality of life and lifespan of older people is a growing area of interest in geriatric medicine. Therapies targeting mitochondria and restoring mitochondrial function are promising treatment strategies. This article provides an overview of stem cell transplantation for sarcopenia, including the mitochondrial delivery pathway and the protective role of stem cells. It also highlights recent advances in preclinical and clinical research on sarcopenia and presents a new treatment method involving stem cell-derived mitochondrial transplantation, outlining its advantages and challenges. Key words: mitochondria, sarcopenia, stem cells, mitochondria quality control
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2023.0210