Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation

• Published in: Journal of clinical medicine 2023-09, Vol.12 (18), p.5855
• Main Authors: Kim, Hack-Lyoung, Joh, Hyun Sung, Lim, Woo-Hyun, Seo, Jae-Bin, Kim, Sang-Hyun, Zo, Joo-Hee, Kim, Myung-A
• Format: Article
• Language: English
• Subjects: Age; Angina pectoris; Arteriosclerosis; Beta blockers; Body mass index; Cardiovascular disease; Care and treatment; Chi-square test; Cholesterol; Clinical medicine; Clinical outcomes; Coronary heart disease; Coronary vessels; Diabetes; Diagnosis; Drug-eluting stents; Ejection fraction; Endocrine system; Heart attacks; Hemoglobin; Hospitals; Hypertension; Ischemia; Medical imaging; Medical prognosis; Mortality; Patient outcomes; Patients; Prognosis; Smoking; Statistical significance; Stroke; Transluminal angioplasty
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12185855

Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing a percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). Methods A total of 4119 consecutive subjects who underwent a PCI with a DES (mean age, 67.1 ± 11.6 years and 33.1% were female) were retrospectively analyzed. ePWV was calculated based on the patient's age and mean blood pressure. Major adverse cardiovascular events (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke, were evaluated. Results During a median follow-up duration of 3.51 years (interquartile range, 1.35-6.37 years), there were 746 MACEs (18.1%). A multivariable analysis showed that a higher ePWV was associated with a higher MACE incidence (middle tertile vs. the lowest tertile: hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.81-3.42; < 0.001; the highest tertile vs. the lowest tertile: HR, 6.18; 95% CI, 4.33-8.80; < 0.001) The inclusion of ePWV data significantly increased the global chi-square values when added to the clinical information (from 96 to 128; < 0.001). Conclusion ePWV demonstrated a significant association with MACEs in patients who underwent DES implantation. Given its relative simplicity to calculate, ePWV could potentially serve as a valuable instrument for stratifying cardiovascular risks within this high-risk patient population.