FRI482 Severe Hypothyroidism: A Lack Of Standardized Care For Patients At Risk Of Myxedema Coma

Disclosure: S. Abdurrahman: None. P. Thakkar: None. E. Kasiri: None. L. Belalcazar: None. Introduction: Myxedema coma (MC) is a rare complication of severe hypothyroidism (HT). MC is diagnosed clinically and often precipitated by a major acute event. While most physicians support rapid and aggressiv...

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Bibliographic Details
Published in:Journal of the Endocrine Society 2023-10, Vol.7 (Supplement_1)
Main Authors: Abdurrahman, Selma, Thakkar, Parin, Kasiri, Elnaz, Belalcazar, L Maria
Format: Article
Language:English
Subjects:
Thyroid
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Summary:Disclosure: S. Abdurrahman: None. P. Thakkar: None. E. Kasiri: None. L. Belalcazar: None. Introduction: Myxedema coma (MC) is a rare complication of severe hypothyroidism (HT). MC is diagnosed clinically and often precipitated by a major acute event. While most physicians support rapid and aggressive management of MC to reduce mortality, there is no consensus on how to approach patients with severe HT at risk of MC. We present two cases that illustrate this treatment gap. Case Presentation: CASE 1: A 76-year-old woman with 9 years of primary HT presented to the hospital after a recent fall; she was found to have an intertrochanteric fracture. The patient reported fatigue, anorexia, and inability to perform activities of daily living. On exam, she was malnourished and intermittently somnolent. Her pulse rate was 84/min; she had no hypothermia. Labs were significant for TSH of 195 mIU/L (0.45 - 4.70 mIU/L) and an undetectable Free T4 (FT4) at
ISSN:2472-1972
2472-1972
DOI:10.1210/jendso/bvad114.1828