Time-dependent diffusion tensor imaging and diffusion modeling of age-related differences in the medial gastrocnemius and feasibility study of correlations to histopathology

Implement STEAM-DTI to model time-dependent diffusion eigenvalues using the random permeable barrier model (RPBM) to study age-related differences in the medial gastrocnemius (MG) muscle. Validate diffusion model-extracted fiber diameter for histological assessment. Diffusion imaging at different di...

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Bibliographic Details
Published in:NMR in biomedicine 2023-11, Vol.36 (11), p.e4996-e4996
Main Authors: Malis, Vadim, Sinha, Usha, Smitaman, Edward, Obra, Jed Keenan Lim, Langer, Henning T, Mossakowski, Agata A, Baar, Keith, Sinha, Shantanu
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Aging - pathology
Aging - physiology
Biological products
Biopsy
Diffusion
Diffusion barriers
Diffusion Tensor Imaging
Eigenvalues
Feasibility Studies
Female
Histology
Histopathology
Humans
Magnetic resonance imaging
Male
Middle Aged
Models, Biological
Muscle, Skeletal - diagnostic imaging
Permeability
Tensors
Time dependence
Time Factors
Young Adult
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Summary:Implement STEAM-DTI to model time-dependent diffusion eigenvalues using the random permeable barrier model (RPBM) to study age-related differences in the medial gastrocnemius (MG) muscle. Validate diffusion model-extracted fiber diameter for histological assessment. Diffusion imaging at different diffusion times (Δ) was performed on seven young and six senior participants. Time-dependent diffusion eigenvalues (λ (t), λ (t), and D (t); average of λ (t) and λ (t)) were fit to the RPBM to extract tissue microstructure parameters. Biopsy of the MG tissue for histological assessment was performed on a subset of participants (four young, six senior). λ (t) was significantly higher in the senior cohort for the range of diffusion times. RPBM fits to λ (t) yielded fiber diameters in agreement to those from histology for both cohorts. The senior cohort had lower values of volume fraction of membranes, ζ, in fits to λ (t), λ (t), and D (t) (significant for fit to λ (t)). Fits of fiber diameter from RPBM to that from histology had the highest correlation for the fit to λ (t). The age-related patterns in λ (t) and λ (t) could tentatively be explained from RPBM fits; these patterns may potentially arise from a decrease in fiber asymmetry and an increase in permeability with age.
ISSN:0952-3480
1099-1492
1099-1492
DOI:10.1002/nbm.4996