196 Serum Trace Minerals and Tumor Necrosis Factor Alpha Concentrations in Prolapsed and Non-Prolapsed Sows

• Published in: Journal of animal science 2023-10, Vol.101 (Supplement_2), p.242-242
• Main Authors: Harshman, Jared A, Carter, Scott D, Daniels, C Scanlon, Coble, Kyle, Madson, Darin
• Format: Article
• Language: English
• Subjects: Calcium; Copper; Hogs; Inductively coupled plasma mass spectrometry; Iron; Magnesium; Manganese; Mass spectrometry; Mass spectroscopy; Minerals; Molybdenum; Pelvic organ prolapse; Selenium; Trace minerals; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Zinc
• ISSN: 0021-8812; 1525-3163
• DOI: 10.1093/jas/skad341.274

Abstract Since 2014, pelvic organ prolapse (POP) has become a growing concern in the U.S. swine industry. Pelvic organ prolapse is one of the three leading causes of sow mortality today. While research has increased over the years investigating the cause and occurrence of POP, the reason for the increase in POP is not fully understood. Trace mineral status is one area of interest proposed to be associated with POP. We conducted a study to determine if there was a difference in serum trace minerals and tumor necrosis factor alpha (TNF-α) concentration between prolapsed and non-prolapsed sows. The study utilized 44 prolapsed sows and 44 non-prolapsed sows of the same parity, location, management, and stage of production. Blood was collected from the prolapsed and non-prolapsed sows upon discovery and processed at a local lab where serum was collected and stored until further analyses were performed. Serum samples were analyzed using inductively coupled plasma mass spectrometry (ICP-MS) for trace mineral content (Ca, Cu, Fe, K, Mg, Mn, Mo, P, Se, and Zn). Additionally, TNF-α concentration was determined from the serum using ELISA testing. Data were analyzed using the PROC GLIMMIX procedure in SAS. Prolapsed sows had decreased (P < 0.05) Fe (2.77 vs 3.76 ppm), Mo (9.22 vs 13.02 ppb), and Zn (1.07 vs 1.19 ppm) trace mineral concentration in the serum compared with the non-prolapsed sows. However, Mg was greater (P < 0.05) in prolapsed sows compared with non-prolapsed sows (23.24 vs 21.36 ppm). Selenium was marginally (P = 0.08) less in prolapsed sows compared with non-prolapsed sows (191 vs 206 ppb). There were no differences (P > 0.10) between prolapsed and non-prolapsed sows trace mineral concentrations for Ca (97.1 vs 99.1 ppm), Cu (2.07 vs 2.03 ppm), Mn (3.77 vs 3.72 ppb), P (52.5 vs 50.2 ppm), and K (264 vs 264 ppm). There was a difference (P < 0.05) in TNF-α concentration between the prolapsed and non-prolapsed sows (233.1 vs 178.9 pg/mL). This study suggests that there is a decreased concentration of various serum trace minerals found in prolapsed sows compared with non-prolapsed sows and an increased TNF-α response in prolapsed sows.