Epigenetic Aging in Older Breast Cancer Survivors and Non-Cancer Controls: Preliminary Findings from the Thinking and Living with Cancer (TLC) Study

Older breast cancer survivors were biologically older than matched non-cancer controls across multiple epigenetic aging measures at 24-months or more after enrollment (which was pre-systemic therapy for survivors). Older breast cancer survivors who had received chemotherapy showed the greatest epige...

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Bibliographic Details
Published in:Cancer 2023-09, Vol.129 (17), p.2741-2753
Main Authors: Rentscher, Kelly E., Bethea, Traci N., Zhai, Wanting, Small, Brent J., Zhou, Xingtao, Ahles, Tim A., Ahn, Jaeil, Breen, Elizabeth C., Cohen, Harvey Jay, Extermann, Martine, Graham, Deena M.A., Jim, Heather S.L., McDonald, Brenna C., Nakamura, Zev M., Patel, Sunita K., Root, James C., Saykin, Andrew J., Van Dyk, Kathleen, Mandelblatt, Jeanne S., Carroll, Judith E.
Format: Article
Language:English
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Summary:Older breast cancer survivors were biologically older than matched non-cancer controls across multiple epigenetic aging measures at 24-months or more after enrollment (which was pre-systemic therapy for survivors). Older breast cancer survivors who had received chemotherapy showed the greatest epigenetic aging, and among this group, an older epigenetic age was associated with worse self-reported cognition relative to controls.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.34818