Ultraviolet photodissociation and collision-induced dissociation for qualitative/quantitative analysis of low molecular weight compounds by liquid chromatography-mass spectrometry

Collision-induced dissociation (CID) is the most wildly used fragmentation technique for qualitative and quantitative determination of low molecular weight compounds (LMWC). Ultraviolet photodissociation (UVPD) has been mainly investigated for the analysis of peptides and lipids while only in a limi...

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Published in:Analytical and bioanalytical chemistry 2023-12, Vol.415 (29-30), p.7117-7126
Main Authors: Giraud, Romain, Le Blanc, Yves J. C., Guna, Mircea, Hopfgartner, Gérard
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Blood plasma
Characterization and Evaluation of Materials
chemical species
Chemistry
Chemistry and Materials Science
Chromatography, Liquid - methods
dissociation
Drug abuse
drugs
Food Science
Fragmentation
Fragments
Humans
Laboratory Medicine
Lipids
Liquid chromatography
Low molecular weights
Mass spectrometry
Mass Spectrometry - methods
Mass spectroscopy
Metabolites
Molecular Weight
Monitoring/Environmental Analysis
Peptides
Peptides - chemistry
Pesticides
Photodissociation
photolysis
Quadrupoles
Qualitative analysis
Quantitative analysis
Research Paper
Ultraviolet Rays
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creator Giraud, Romain
Le Blanc, Yves J. C.
Guna, Mircea
Hopfgartner, Gérard
description Collision-induced dissociation (CID) is the most wildly used fragmentation technique for qualitative and quantitative determination of low molecular weight compounds (LMWC). Ultraviolet photodissociation (UVPD) has been mainly investigated for the analysis of peptides and lipids while only in a limited way for LMWC. A triple quadrupole linear ion trap instrument has been modified to allow ultraviolet photodissociation (UVPD) in the end of the q2 region enabling various workflows with and without data-dependent acquisition (DDA) combining CID and UVPD in the same LC–MS analysis. The performance of UVPD, with a 266-nm laser, is compared to CID for a mix of 90 molecules from different classes of LMWC including peptides, pesticides, pharmaceuticals, metabolites, and drugs of abuse. These two activation methods offer complementary fragments as well as common fragments with similar sensitivities for most analytes investigated. The versatility of UVPD and CID is also demonstrated for quantitative analysis in human plasma of bosentan and its desmethyl metabolite, used as model analytes. Different background signals are observed for both fragmentation methods as well as unique fragments which opens the possibility of developing a selective quantitative assay with improved sample throughput, in particular for analytes present in different matrices. Graphical Abstract
doi_str_mv 10.1007/s00216-023-04977-0
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subjects Analytical Chemistry
Biochemistry
Blood plasma
Characterization and Evaluation of Materials
chemical species
Chemistry
Chemistry and Materials Science
Chromatography, Liquid - methods
dissociation
Drug abuse
drugs
Food Science
Fragmentation
Fragments
Humans
Laboratory Medicine
Lipids
Liquid chromatography
Low molecular weights
Mass spectrometry
Mass Spectrometry - methods
Mass spectroscopy
Metabolites
Molecular Weight
Monitoring/Environmental Analysis
Peptides
Peptides - chemistry
Pesticides
Photodissociation
photolysis
Quadrupoles
Qualitative analysis
Quantitative analysis
Research Paper
Ultraviolet Rays
title Ultraviolet photodissociation and collision-induced dissociation for qualitative/quantitative analysis of low molecular weight compounds by liquid chromatography-mass spectrometry
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