First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

Abstract Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased dose...

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Published in:Journal of the Pediatric Infectious Diseases Society 2023-11, Vol.12 (11), p.581-585
Main Authors: Chabala, Chishala, Jacobs, Tom G, Moraleda, Cinta, Ndaferankhande, John M, Mumbiro, Vivian, Passanduca, Alfeu, Namuziya, Natasha, Nalwanga, Damalie, Musiime, Victor, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Chitsamatanga, Moses, Cassia, Uneisse, Nduna, Bwendo, Bramugy, Justina, Sacarlal, Jahit, Madrid, Lola, Nathoo, Kusum J, Colbers, Angela, Burger, David M, Mulenga, Veronica, Buck, W Chris, Mujuru, Hilda A, te Brake, Lindsey H M, Rojo, Pablo, Tagarro, Alfredo, Aarnoutse, Rob E
Format: Article
Language:English
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Brief Reports
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Summary:Abstract Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants. First-line antituberculosis drug peak concentrations in infants with HIV were low compared with reference values for adults. The percent peak concentrations within adult reference values were 51%, 22%, 76%, and 6% for isoniazid, rifampicin, pyrazinamide, and ethambutol, respectively.
ISSN:2048-7207
2048-7193
2048-7207
DOI:10.1093/jpids/piad088