Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders

Introduction: Suicidal thoughts and behaviors have partially distinct genetic etiologies. Methods: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-harm ideation, nonfatal suicide attempt, death by suicide, and depression. Using mixed-effe...

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Published in:Complex psychiatry 2023-01, Vol.9 (1-4), p.11-23
Main Authors: Colbert, Sarah M.C., Mullins, Niamh, Chan, Grace, Meyers, Jacquelyn L., Schulman, Jessica, Kuperman, Samuel, Lai, Dongbing, Nurnberger, John, Plawecki, Martin H., Kamarajan, Chella, Anokhin, Andrey P., Bucholz, Kathleen K., Hesselbrock, Victor, Edenberg, Howard J., Kramer, John, Dick, Danielle M., Porjesz, Bernice, Agrawal, Arpana, Johnson, Emma C.
Format: Article
Language:English
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Research Article
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Summary:Introduction: Suicidal thoughts and behaviors have partially distinct genetic etiologies. Methods: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-harm ideation, nonfatal suicide attempt, death by suicide, and depression. Using mixed-effect models, we estimated whether these PRSs were associated with a range of suicidal thoughts and behaviors in the Collaborative Study on the Genetics of Alcoholism (N = 7,526). Results: All PRSs were significantly associated with suicidal ideation and suicide attempt (betas = 0.08–0.44, false discovery rate [FDR]
ISSN:2673-3005
2673-298X
DOI:10.1159/000529164