A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease

The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with...

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Bibliographic Details
Published in:The journal of physiological sciences 2019-11, Vol.69 (6), p.969-979
Main Authors: Miki, Keisuke, Kitada, Seigo, Miki, Mari, Hui, Shu-Ping, Shrestha, Rojeet, Yoshimura, Kenji, Tsujino, Kazuyuki, Kagawa, Hiroyuki, Oshitani, Yohei, Kida, Hiroshi, Maekura, Ryoji, Kangawa, Kenji
Format: Article
Language:English
Subjects:
Acylation
Aerobic capacity
Amino acids
Chronic obstructive pulmonary disease
Clinical trials
Drug Therapy, Combination
Exercise
Fitness training programs
Ghrelin
Ghrelin - administration & dosage
Ghrelin - pharmacology
Heart
Humans
Intravenous administration
Lung diseases
Muscle strength
Obstructive lung disease
Octanoic acid
Original Paper
Oxygen
Patients
Peak Expiratory Flow Rate - drug effects
Peptides
Physical fitness
Plasma
Pulmonary Disease, Chronic Obstructive - drug therapy
Questionnaires
Sample size
Thinness - drug therapy
Triglycerides
Triglycerides - administration & dosage
Triglycerides - chemistry
Triglycerides - pharmacology
Underweight
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Summary:The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT-ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O pulse, and to the difference between inspired and expired oxygen concentration rather than minute ventilation. Addition of dietary MCT to ghrelin treatment improved the aerobic capacity of underweight COPD patients, likely by mechanisms of increased O delivery through improvements in primary cardiocirculatory and muscular crosstalk.
ISSN:1880-6546
1880-6562
DOI:10.1007/s12576-019-00716-2