Low muscle mass is associated with a higher risk of all–cause and cardiovascular disease–specific mortality in cancer survivors

•We conducted survival analysis for cancer survivors and their cancer-free counterparts by muscle mass.•Cancer survivors with low muscle mass are more likely to die or have fatal cardiovascular events.•Compared with their cancer-free counterparts, the effects of low muscle mass on mortality are stro...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-03, Vol.107, p.111934-111934, Article 111934
Main Authors: Zhang, Dongyu, Spiropoulos, Kori A., Wijayabahu, Akemi, Christou, Demetra D., Karanth, Shama D., Anton, Stephen D., Leeuwenburgh, Christiaan, Liang, Muxuan, Wheeler, Meghann, Yang, Danting, Livingstone, Aduse-Poku, Mankowski, Robert T., Cheng, Ting-Yuan David, Zhang, Hanchao, Siegel, Erin M., Penedo, Frank J., Licht, Jonathan D., Braithwaite, Dejana
Format: Article
Language:English
Subjects:
Adult
Body height
Cancer
Cancer Survivors
Cancer survivorship
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Death
Diagnosis
Energy consumption
Epidemiology
Female
Geriatric oncology
Heart diseases
Humans
Low muscle mass
Male
Mortality
Muscles
Neoplasms - complications
Nutrition
Nutrition Surveys
Older people
Prognosis
Risk
Risk Factors
Statistical analysis
Statistical models
Survival
Womens health
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Summary:•We conducted survival analysis for cancer survivors and their cancer-free counterparts by muscle mass.•Cancer survivors with low muscle mass are more likely to die or have fatal cardiovascular events.•Compared with their cancer-free counterparts, the effects of low muscle mass on mortality are stronger in cancer survivors. Individuals with prior cancer diagnosis are more likely to have low muscle mass (LMM) than their cancer-free counterparts. Understanding the effects of LMM on the prognosis of cancer survivors can be clinically important. The aim of this study was to investigate whether risks for all-cause and cardiovascular disease (CVD)–specific mortality differ by status of LMM in cancer survivors and a matched cohort without cancer history. We used cohort data from the 1999–2006 and 2011–2014 National Health and Nutrition Examination Survey. Participants included 946 adults surviving for ≥1 since cancer diagnosis and a matched cohort (by age, sex, and race) without cancer history (N = 1857). LMM was defined by appendicular lean mass and body height (men
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2022.111934