Effect of Silicone Patch Containing Metal-organic Framework on Hypertrophic Scar Suppression

Hypertrophic scars (HS) are an abnormal cutaneous condition of wound healing characterized by excessive fibrosis and disrupted collagen deposition. This study assessed the potential of a silicone patch embedded with chemically stable zirconium-based metal-organic frameworks (MOF)-808 structures to m...

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Bibliographic Details
Published in:In vivo (Athens) 2024-01, Vol.38 (1), p.235-245
Main Authors: Zhang, Xin Rui, Ryu, Unjin, Najmiddinov, Bakhtiyor, Trinh, Thuy-Tien Thi, Choi, Kyung Min, Nam, Sun-Young, Heo, Chan Yeong
Format: Article
Language:English
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Summary:Hypertrophic scars (HS) are an abnormal cutaneous condition of wound healing characterized by excessive fibrosis and disrupted collagen deposition. This study assessed the potential of a silicone patch embedded with chemically stable zirconium-based metal-organic frameworks (MOF)-808 structures to mitigate HS formation using a rabbit ear model. A silicone patch was strategically engineered by incorporating Zr-MOF-808, a composite structure comprising metal ions and organic ligands. Structural integrity of the Zr-MOF-808 silicone patch was validated using scanning electron microscopy and X-ray diffraction analysis. The animals were divided into three groups: a control, no treatment group (Group 1), a silicone patch treatment group (Group 2), and a group treated with a 0.2% loaded Zr-MOF-808 silicone patch (Group 3). HS suppression effects were quantified using scar elevation index (SEI), dorsal skin thickness measurements, and myofibroblast protein expression. Histopathological examination of post-treatment HS samples revealed substantial reductions in SEI (34.6%) and epidermal thickness (49.5%) in Group 3. Scar hyperplasia was significantly diminished by 53.5% (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.13430