Cellular models in autoinflammatory disease research

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders caused by dysregulation of the innate immune system. Understanding the complex mechanisms underlying these conditions is critical for developing effective treatments. Cellular models are essential for identifying...

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Bibliographic Details
Published in:Clinical & translational immunology 2024, Vol.13 (1), p.e1481-n/a
Main Authors: Şen, Başak, Balcı‐Peynircioğlu, Banu
Format: Article
Language:English
Subjects:
autoinflammation
disease modelling
induced pluripotent stem cell
Review
systemic autoinflammatory diseases
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Summary:Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders caused by dysregulation of the innate immune system. Understanding the complex mechanisms underlying these conditions is critical for developing effective treatments. Cellular models are essential for identifying new conditions and studying their pathogenesis. Traditionally, these studies have used primary cells and cell lines of disease‐relevant cell types, although newer induced pluripotent stem cell (iPSC)‐based models might have unique advantages. In this review, we discuss the three cellular models used in autoinflammatory disease research, their strengths and weaknesses, and their applications to inform future research in the field. Understanding the complex mechanisms underlying systemic autoinflammatory diseases is critical for developing effective treatments. Cellular models are essential for identifying new conditions and studying their pathogenesis. In this review, we discuss the different cellular models used in autoinflammatory disease research, their strengths and weaknesses, and their applications.
ISSN:2050-0068
2050-0068
DOI:10.1002/cti2.1481