Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: A secondary analysis of the ASPIRIN trial

Objective To assess the impact of low‐dose aspirin (LDA) starting in early pregnancy on delaying preterm hypertensive disorders of pregnancy. Design Non‐prespecified secondary analysis of a randomised masked trial of LDA. Setting The study was conducted among women in the Global Network for Women�...

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Published in:BJOG : an international journal of obstetrics and gynaecology 2023-11, Vol.130 (S3), p.16-25
Main Authors: Kavi, Avinash, Hoffman, Matthew K., Somannavar, Manjunath S., Metgud, Mrityunjay C., Goudar, Shivaprasad S., Moore, Janet, Nielsen, Eleanor, Goco, Norman, McClure, Elizabeth M., Lokangaka, Adrien, Tshefu, Antoinette, Bauserman, Melissa, Mwenechanya, Musaku, Chomba, Elwyn, Carlo, Waldemar A., Figueroa, Lester, Krebs, Nancy F., Jessani, Saleem, Saleem, Sarah, Goldenberg, Robert L., Das, Prabirkumar, Patel, Archana, Hibberd, Patricia L., Esamai, Fabian, Bucher, Sherri, Koso‐Thomas, Marion, Silver, Robert, Derman, Richard J.
Format: Article
Language:English
Subjects:
Age
Aspirin
Aspirin - therapeutic use
Child
Child Health
Female
Fetal Growth Retardation - drug therapy
Gestational age
Humans
Hypertension
Hypertension, Pregnancy-Induced - drug therapy
Hypertension, Pregnancy-Induced - epidemiology
Hypertension, Pregnancy-Induced - prevention & control
hypertensive disorders of pregnancy
Infant
Infant, Newborn
low‐ and middle‐income countries
Mortality
nulliparous
Parity
Perinatal Death
Placebos
Population studies
Pregnancy
Pregnant Women
preterm
Prospective Studies
Small for gestational age
Women's Health
Womens health
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Summary:Objective To assess the impact of low‐dose aspirin (LDA) starting in early pregnancy on delaying preterm hypertensive disorders of pregnancy. Design Non‐prespecified secondary analysis of a randomised masked trial of LDA. Setting The study was conducted among women in the Global Network for Women's and Children's Health's Maternal and Newborn Health Registry (MNHR) clusters, a prospective, population‐based study in Kenya, Zambia, the Democratic Republic of the Congo (DRC), Pakistan, India (two sites‐Belagavi and Nagpur) and Guatemala. Population Nulliparous singleton pregnancies between 6+0 weeks and 13+6 weeks in six low‐middle income countries (Democratic Republic of Congo, Guatemala, India, Kenya, Pakistan, Zambia) enrolled in the ASPIRIN Trial. Methods We compared the incidence of HDP at delivery at three gestational age periods (
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.17607