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The association between gut microbiome and growth in infants with cystic fibrosis
In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight...
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| Published in: | Journal of cystic fibrosis 2023-11, Vol.22 (6), p.1010-1016 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 1016 |
| container_issue | 6 |
| container_start_page | 1010 |
| container_title | Journal of cystic fibrosis |
| container_volume | 22 |
| creator | Deschamp, A R Chen, Y Wang, W F Rasic, M Hatch, J Sanders, D B Ranganathan, S C Ferkol, T Perkins, D Finn, P Davis, S D |
| description | In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight into future nutritional management in CF.
Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups.
Infants with CF (N = 78) were enrolled as part of a larger study. AUS-CF infants had higher mean weight-for-age z-scores than US-CF infants (p = 0.02). A subset of participants (CF N = 40, non-CF disease controls N = 10) provided stool samples for microbiome analysis. AUS-CF infants had lower stool alpha diversity compared to US-CF infants (p |
| doi_str_mv | 10.1016/j.jcf.2023.08.001 |
| format | article |
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Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups.
Infants with CF (N = 78) were enrolled as part of a larger study. AUS-CF infants had higher mean weight-for-age z-scores than US-CF infants (p = 0.02). A subset of participants (CF N = 40, non-CF disease controls N = 10) provided stool samples for microbiome analysis. AUS-CF infants had lower stool alpha diversity compared to US-CF infants (p < 0.001). AUS-CF infants had higher relative abundance of stool Proteobacteria compared to US-CF infants which was associated with antibiotic prophylaxis (p < 0.001). Malnutrition (weight-for-age <10th percentile) was associated with depleted Lactococcus (p < 0.001). Antibiotic prophylaxis (p = 0.002) and malnutrition (p = 0.012) were linked with predicted decreased activity of metabolic pathways responsible for short chain fatty acid processing.
In infants with CF, gut microbiome composition and diversity differed between the two continents. Gut microbial diversity was not linked to growth. The relationship between malnutrition and antibiotic prophylaxis with reduced SCFA fermentation could have implications for gut health and function and warrants additional investigation.</description><identifier>ISSN: 1569-1993</identifier><identifier>ISSN: 1873-5010</identifier><identifier>EISSN: 1873-5010</identifier><identifier>DOI: 10.1016/j.jcf.2023.08.001</identifier><identifier>PMID: 37598041</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Cystic Fibrosis - complications ; Feces - microbiology ; Female ; Gastrointestinal Microbiome ; Gastrointestinal Tract ; Humans ; Infant ; Malnutrition - diagnosis ; Malnutrition - etiology ; RNA, Ribosomal, 16S - genetics</subject><ispartof>Journal of cystic fibrosis, 2023-11, Vol.22 (6), p.1010-1016</ispartof><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d451cf4cc49cba0e72ece7e9530a6783969949e4e48a297724d9a6edb066c5963</citedby><cites>FETCH-LOGICAL-c357t-d451cf4cc49cba0e72ece7e9530a6783969949e4e48a297724d9a6edb066c5963</cites><orcidid>0000-0003-4703-6177 ; 0000-0001-6265-6249 ; 0000-0002-7401-2421 ; 0000-0001-6497-7927 ; 0000-0002-9390-0651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37598041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deschamp, A R</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><creatorcontrib>Wang, W F</creatorcontrib><creatorcontrib>Rasic, M</creatorcontrib><creatorcontrib>Hatch, J</creatorcontrib><creatorcontrib>Sanders, D B</creatorcontrib><creatorcontrib>Ranganathan, S C</creatorcontrib><creatorcontrib>Ferkol, T</creatorcontrib><creatorcontrib>Perkins, D</creatorcontrib><creatorcontrib>Finn, P</creatorcontrib><creatorcontrib>Davis, S D</creatorcontrib><title>The association between gut microbiome and growth in infants with cystic fibrosis</title><title>Journal of cystic fibrosis</title><addtitle>J Cyst Fibros</addtitle><description>In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight into future nutritional management in CF.
Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups.
Infants with CF (N = 78) were enrolled as part of a larger study. AUS-CF infants had higher mean weight-for-age z-scores than US-CF infants (p = 0.02). A subset of participants (CF N = 40, non-CF disease controls N = 10) provided stool samples for microbiome analysis. AUS-CF infants had lower stool alpha diversity compared to US-CF infants (p < 0.001). AUS-CF infants had higher relative abundance of stool Proteobacteria compared to US-CF infants which was associated with antibiotic prophylaxis (p < 0.001). Malnutrition (weight-for-age <10th percentile) was associated with depleted Lactococcus (p < 0.001). Antibiotic prophylaxis (p = 0.002) and malnutrition (p = 0.012) were linked with predicted decreased activity of metabolic pathways responsible for short chain fatty acid processing.
In infants with CF, gut microbiome composition and diversity differed between the two continents. Gut microbial diversity was not linked to growth. The relationship between malnutrition and antibiotic prophylaxis with reduced SCFA fermentation could have implications for gut health and function and warrants additional investigation.</description><subject>Cystic Fibrosis - complications</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>Gastrointestinal Tract</subject><subject>Humans</subject><subject>Infant</subject><subject>Malnutrition - diagnosis</subject><subject>Malnutrition - etiology</subject><subject>RNA, Ribosomal, 16S - genetics</subject><issn>1569-1993</issn><issn>1873-5010</issn><issn>1873-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVUU1r3DAQFaGhu036A3IpPvZiZ2R9n0oJaRpYCIHkLGR5vKtlbaWWtkv-fRWyCQ0MzAzz5s3wHiEXFBoKVF5um60fmhZa1oBuAOgJWVKtWC2AwqdSC2lqagxbkC8pbQtAgdKfyYIpYTRwuiT3DxusXErRB5dDnKoO8wFxqtb7XI3Bz7ELcSyQqa_WczzkTRWmEoObcqoOofT-OeXgqyF0c0whnZPTwe0Sfj3mM_L46_rh6ne9uru5vfq5qj0TKtc9F9QP3HtufOcAVYseFRrBwEmlmZHGcIMcuXatUarlvXES-w6k9MJIdkZ-vPI-7bsRe49Tnt3OPs1hdPOzjS7Yj5MpbOw6_rUUNAepTGH4fmSY4589pmzHkDzudm7CuE-21YIZLgVVBUpfoUWQlGYc3u9QsC9e2K0tXtgXLyxoW6QuO9_-f_B940189g-1YofA</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Deschamp, A R</creator><creator>Chen, Y</creator><creator>Wang, W F</creator><creator>Rasic, M</creator><creator>Hatch, J</creator><creator>Sanders, D B</creator><creator>Ranganathan, S C</creator><creator>Ferkol, T</creator><creator>Perkins, D</creator><creator>Finn, P</creator><creator>Davis, S D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4703-6177</orcidid><orcidid>https://orcid.org/0000-0001-6265-6249</orcidid><orcidid>https://orcid.org/0000-0002-7401-2421</orcidid><orcidid>https://orcid.org/0000-0001-6497-7927</orcidid><orcidid>https://orcid.org/0000-0002-9390-0651</orcidid></search><sort><creationdate>20231101</creationdate><title>The association between gut microbiome and growth in infants with cystic fibrosis</title><author>Deschamp, A R ; Chen, Y ; Wang, W F ; Rasic, M ; Hatch, J ; Sanders, D B ; Ranganathan, S C ; Ferkol, T ; Perkins, D ; Finn, P ; Davis, S D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d451cf4cc49cba0e72ece7e9530a6783969949e4e48a297724d9a6edb066c5963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cystic Fibrosis - complications</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>Gastrointestinal Tract</topic><topic>Humans</topic><topic>Infant</topic><topic>Malnutrition - diagnosis</topic><topic>Malnutrition - etiology</topic><topic>RNA, Ribosomal, 16S - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deschamp, A R</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><creatorcontrib>Wang, W F</creatorcontrib><creatorcontrib>Rasic, M</creatorcontrib><creatorcontrib>Hatch, J</creatorcontrib><creatorcontrib>Sanders, D B</creatorcontrib><creatorcontrib>Ranganathan, S C</creatorcontrib><creatorcontrib>Ferkol, T</creatorcontrib><creatorcontrib>Perkins, D</creatorcontrib><creatorcontrib>Finn, P</creatorcontrib><creatorcontrib>Davis, S D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cystic fibrosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deschamp, A R</au><au>Chen, Y</au><au>Wang, W F</au><au>Rasic, M</au><au>Hatch, J</au><au>Sanders, D B</au><au>Ranganathan, S C</au><au>Ferkol, T</au><au>Perkins, D</au><au>Finn, P</au><au>Davis, S D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between gut microbiome and growth in infants with cystic fibrosis</atitle><jtitle>Journal of cystic fibrosis</jtitle><addtitle>J Cyst Fibros</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>22</volume><issue>6</issue><spage>1010</spage><epage>1016</epage><pages>1010-1016</pages><issn>1569-1993</issn><issn>1873-5010</issn><eissn>1873-5010</eissn><abstract>In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight into future nutritional management in CF.
Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups.
Infants with CF (N = 78) were enrolled as part of a larger study. AUS-CF infants had higher mean weight-for-age z-scores than US-CF infants (p = 0.02). A subset of participants (CF N = 40, non-CF disease controls N = 10) provided stool samples for microbiome analysis. AUS-CF infants had lower stool alpha diversity compared to US-CF infants (p < 0.001). AUS-CF infants had higher relative abundance of stool Proteobacteria compared to US-CF infants which was associated with antibiotic prophylaxis (p < 0.001). Malnutrition (weight-for-age <10th percentile) was associated with depleted Lactococcus (p < 0.001). Antibiotic prophylaxis (p = 0.002) and malnutrition (p = 0.012) were linked with predicted decreased activity of metabolic pathways responsible for short chain fatty acid processing.
In infants with CF, gut microbiome composition and diversity differed between the two continents. Gut microbial diversity was not linked to growth. The relationship between malnutrition and antibiotic prophylaxis with reduced SCFA fermentation could have implications for gut health and function and warrants additional investigation.</abstract><cop>Netherlands</cop><pmid>37598041</pmid><doi>10.1016/j.jcf.2023.08.001</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4703-6177</orcidid><orcidid>https://orcid.org/0000-0001-6265-6249</orcidid><orcidid>https://orcid.org/0000-0002-7401-2421</orcidid><orcidid>https://orcid.org/0000-0001-6497-7927</orcidid><orcidid>https://orcid.org/0000-0002-9390-0651</orcidid></addata></record> |
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| identifier | ISSN: 1569-1993 |
| ispartof | Journal of cystic fibrosis, 2023-11, Vol.22 (6), p.1010-1016 |
| issn | 1569-1993 1873-5010 1873-5010 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Cystic Fibrosis - complications Feces - microbiology Female Gastrointestinal Microbiome Gastrointestinal Tract Humans Infant Malnutrition - diagnosis Malnutrition - etiology RNA, Ribosomal, 16S - genetics |
| title | The association between gut microbiome and growth in infants with cystic fibrosis |
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