Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data

Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). We aimed to investigate the...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2022-12, Vol.116 (6), p.1864-1876
Main Authors: Liu, Enju, Wang, Dongqing, Darling, Anne M, Perumal, Nandita, Wang, Molin, Ahmed, Tahmeed, Christian, Parul, Dewey, Kathryn G, Kac, Gilberto, Kennedy, Stephen, Subramoney, Vishak, Briggs, Brittany, Fawzi, Wafaie W
Format: Article
Language:English
Subjects:
Adequacy
Body Mass Index
Developing Countries
Dietary supplements
Female
Folic Acid
Gestational Weight Gain
Heterogeneity
Humans
Income
Iron
Lipids
Low income groups
low- and middle-income countries
Meta-analysis
multiple micronutrient supplements
Nutrients
Pregnancy
Pregnancy Outcome
Prenatal experience
randomized controlled trials
Risk management
Risk reduction
small-quantity lipid-based nutrient supplements
Vitamin B
Vitamins
Women's Nutrition
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Summary:Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). We aimed to investigate the effects of multiple micronutrient supplements (MMSs) and small-quantity lipid-based nutrient supplements (LNSs) on GWG in LMICs. A 2-stage meta-analysis of individual participant data was conducted to examine the effects of MMSs (45,507 women from 14 trials) and small-quantity LNSs (6237 women from 4 trials) on GWG compared with iron and folic acid supplements only. Percentage adequacy of GWG and total weight gain at delivery were calculated according to the IOM 2009 guidelines. Binary outcomes included severely inadequate (percentage adequacy
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqac259