Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

Pigs infected with hemolytic F4(+) strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4(+) enterotoxigenic E. coli to cause septicemia in swine following oral ino...

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Bibliographic Details
Published in:Infection and immunity 1998-10, Vol.66 (10), p.5031-5035
Main Authors: Moxley, R.A, Berberov, E.M, Francis, D.H, Xing, J, Moayeri, M, Welch, R.A, Baker, D.R, Barletta, R.G
Format: Article
Language:English
Subjects:
Animals
Bacteremia - veterinary
Bacterial diseases
Bacterial Proteins - genetics
Bacterial Toxins - biosynthesis
Bacteriology
Biological and medical sciences
Enterotoxins - biosynthesis
Escherichia coli - genetics
Escherichia coli - pathogenicity
Escherichia coli Infections - veterinary
Escherichia coli Proteins
Experimental bacterial diseases and models
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Germ-Free Life
Hemolysin Proteins - genetics
hemolysins
Infectious diseases
Jejunum - microbiology
Medical sciences
Microbiology
Molecular and Cellular Pathogenesis
mutants
Mutation
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Swine
Swine Diseases - microbiology
virulence
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Summary:Pigs infected with hemolytic F4(+) strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4(+) enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.66.10.5031-5035.1998