Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mort...

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Bibliographic Details
Published in:npj aging 2024-02, Vol.10 (1), p.15-15, Article 15
Main Authors: Shek, Naomi, Choy, Anna-Maria, Lang, Chim C., Miller, Bruce E., Tal-Singer, Ruth, Bolton, Charlotte E., Thomson, Neil C., Chalmers, James D., Bown, Matt J., Newby, David E., Khan, Faisel, Huang, Jeffrey T. J.
Format: Article
Language:English
Subjects:
631/45
692/699/75
Age
Aging
Biomedical and Life Sciences
Biomedicine
Brief Communication
Cell Physiology
Chronic obstructive pulmonary disease
Elastin
Geriatrics/Gerontology
Human Physiology
Hypertension
Medicine
Mortality
Neurosciences
Physiology
Rheumatoid arthritis
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Summary:Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
ISSN:2731-6068
2731-6068
2056-3973
DOI:10.1038/s41514-024-00143-7