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Crosstalk between vault RNAs and innate immunity
Purpose Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary stru...
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| Published in: | Molecular biology reports 2024-12, Vol.51 (1), p.387-387, Article 387 |
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| Main Authors: | , |
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| Language: | English |
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| container_end_page | 387 |
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| container_title | Molecular biology reports |
| container_volume | 51 |
| creator | Avila-Bonilla, Rodolfo Gamaliel Martínez-Montero, Juan Pablo |
| description | Purpose
Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses. However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
Results
In this review, we summarized the biology of vtRNAs and focused on their interactions with the innate immune system. These findings provide insights into the diverse roles of vtRNAs and their correlation with various cellular processes to improve our understanding of their biological functions. |
| doi_str_mv | 10.1007/s11033-024-09305-y |
| format | article |
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Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses. However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
Results
In this review, we summarized the biology of vtRNAs and focused on their interactions with the innate immune system. These findings provide insights into the diverse roles of vtRNAs and their correlation with various cellular processes to improve our understanding of their biological functions.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-024-09305-y</identifier><identifier>PMID: 38443657</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acids ; Aging ; Animal Anatomy ; Animal Biochemistry ; Apoptosis ; Autoimmune diseases ; Autophagy ; Biomedical and Life Sciences ; Biosynthesis ; Cancer ; Cytokines ; DNA-directed RNA polymerase ; Drug resistance ; eIF-2 kinase ; Gene expression ; Histology ; Immune system ; Immunity, Innate - genetics ; Immunology ; Inflammation ; Innate immunity ; Interferon ; Interferon-inducible protein ; Interferons ; Kinases ; Life Sciences ; Molecular biology ; Morphology ; Physiology ; Protein kinase R ; Proteins ; Retinoic acid ; Review ; Ribonuclease L ; RNA polymerase ; Roles ; Sensors ; Transcription factors ; Tumor necrosis factor-TNF ; Viral infections</subject><ispartof>Molecular biology reports, 2024-12, Vol.51 (1), p.387-387, Article 387</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-687e4b0aa4fbde896835f788319f9a6a259732a0d80ef1f38c04ff1d1597dec13</cites><orcidid>0009-0005-1222-5826 ; 0000-0002-0582-0046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38443657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avila-Bonilla, Rodolfo Gamaliel</creatorcontrib><creatorcontrib>Martínez-Montero, Juan Pablo</creatorcontrib><title>Crosstalk between vault RNAs and innate immunity</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Purpose
Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses. However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
Results
In this review, we summarized the biology of vtRNAs and focused on their interactions with the innate immune system. These findings provide insights into the diverse roles of vtRNAs and their correlation with various cellular processes to improve our understanding of their biological functions.</description><subject>Acids</subject><subject>Aging</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Apoptosis</subject><subject>Autoimmune diseases</subject><subject>Autophagy</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Cancer</subject><subject>Cytokines</subject><subject>DNA-directed RNA polymerase</subject><subject>Drug resistance</subject><subject>eIF-2 kinase</subject><subject>Gene expression</subject><subject>Histology</subject><subject>Immune system</subject><subject>Immunity, Innate - genetics</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Interferon-inducible protein</subject><subject>Interferons</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>Physiology</subject><subject>Protein kinase R</subject><subject>Proteins</subject><subject>Retinoic acid</subject><subject>Review</subject><subject>Ribonuclease L</subject><subject>RNA polymerase</subject><subject>Roles</subject><subject>Sensors</subject><subject>Transcription factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Viral infections</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctOwzAQRS0EoqXwAyxQJDZsAuPYju0VqipeUgUSgrXlJnZJSZwSJ0X9e1xaymPBypLnzLVnDkLHGM4xAL_wGAMhMSQ0BkmAxcsd1MeMk5hKLnZRHwjgmAqGe-jA-xkAUMzZPuoRQSlJGe8jGDW1960uX6OJad-NcdFCd2UbPd4PfaRdHhXO6dZERVV1rmiXh2jP6tKbo805QM_XV0-j23j8cHM3Go7jjCZpG6eCGzoBramd5EbIVBBmuRAESyt1qhMmOUk05AKMxZaIDKi1OMfhPjcZJgN0uc6dd5PK5JlxbaNLNW-KSjdLVetC_a644kVN64XCIDGVQEPC2Sahqd8641tVFT4zZamdqTuvEklEEpbDeUBP_6CzumtcmG9FcZoyyVigkjWVrXbWGLv9DQa1MqLWRlQwoj6NqGVoOvk5x7blS0EAyBrwoeSmpvl--5_YD2Tclos</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Avila-Bonilla, Rodolfo Gamaliel</creator><creator>Martínez-Montero, Juan Pablo</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0005-1222-5826</orcidid><orcidid>https://orcid.org/0000-0002-0582-0046</orcidid></search><sort><creationdate>20241201</creationdate><title>Crosstalk between vault RNAs and innate immunity</title><author>Avila-Bonilla, Rodolfo Gamaliel ; Martínez-Montero, Juan Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-687e4b0aa4fbde896835f788319f9a6a259732a0d80ef1f38c04ff1d1597dec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>Aging</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Apoptosis</topic><topic>Autoimmune diseases</topic><topic>Autophagy</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Cancer</topic><topic>Cytokines</topic><topic>DNA-directed RNA polymerase</topic><topic>Drug resistance</topic><topic>eIF-2 kinase</topic><topic>Gene expression</topic><topic>Histology</topic><topic>Immune system</topic><topic>Immunity, Innate - genetics</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Innate immunity</topic><topic>Interferon</topic><topic>Interferon-inducible protein</topic><topic>Interferons</topic><topic>Kinases</topic><topic>Life Sciences</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>Physiology</topic><topic>Protein kinase R</topic><topic>Proteins</topic><topic>Retinoic acid</topic><topic>Review</topic><topic>Ribonuclease L</topic><topic>RNA polymerase</topic><topic>Roles</topic><topic>Sensors</topic><topic>Transcription factors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avila-Bonilla, Rodolfo Gamaliel</creatorcontrib><creatorcontrib>Martínez-Montero, Juan Pablo</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avila-Bonilla, Rodolfo Gamaliel</au><au>Martínez-Montero, Juan Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crosstalk between vault RNAs and innate immunity</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>51</volume><issue>1</issue><spage>387</spage><epage>387</epage><pages>387-387</pages><artnum>387</artnum><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Purpose
Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses. However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
Results
In this review, we summarized the biology of vtRNAs and focused on their interactions with the innate immune system. These findings provide insights into the diverse roles of vtRNAs and their correlation with various cellular processes to improve our understanding of their biological functions.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38443657</pmid><doi>10.1007/s11033-024-09305-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0009-0005-1222-5826</orcidid><orcidid>https://orcid.org/0000-0002-0582-0046</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular biology reports, 2024-12, Vol.51 (1), p.387-387, Article 387 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10914904 |
| source | Springer Nature |
| subjects | Acids Aging Animal Anatomy Animal Biochemistry Apoptosis Autoimmune diseases Autophagy Biomedical and Life Sciences Biosynthesis Cancer Cytokines DNA-directed RNA polymerase Drug resistance eIF-2 kinase Gene expression Histology Immune system Immunity, Innate - genetics Immunology Inflammation Innate immunity Interferon Interferon-inducible protein Interferons Kinases Life Sciences Molecular biology Morphology Physiology Protein kinase R Proteins Retinoic acid Review Ribonuclease L RNA polymerase Roles Sensors Transcription factors Tumor necrosis factor-TNF Viral infections |
| title | Crosstalk between vault RNAs and innate immunity |
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